G alpha (q) inhibits PI3K alpha

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).

Literature References
PubMed ID Title Journal Year
16268778 Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras

Ballou, LM, Chattopadhyay, M, Li, Y, Scarlata, S, Lin, RZ

Biochem J 2006
18515384 Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways

Golebiewska, U, Scarlata, S

Biophys J 2008
Participant Of
Orthologous Events
Cite Us!