Reactome | G alpha (q) inhibits PI3K alpha

G alpha (q) inhibits PI3K alpha

Stable Identifier

R-HSA-416358

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).

Literature References

PubMed ID	Title	Journal	Year
16268778	Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras Ballou, LM, Chattopadhyay, M, Li, Y, Scarlata, S, Lin, RZ	Biochem J	2006
18515384	Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways Golebiewska, U, Scarlata, S	Biophys J	2008