G alpha (q) inhibits PI3K alpha

Stable Identifier
R-HSA-416358
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Summation

Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).

Literature References
PubMed ID Title Journal Year
16268778 Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras

Ballou, LM, Chattopadhyay, M, Li, Y, Scarlata, S, Lin, RZ

Biochem J 2006
18515384 Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways

Golebiewska, U, Scarlata, S

Biophys J 2008
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