Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).

• G alpha (q) inhibits PI3K alpha (Bos taurus)
• G alpha (q) inhibits PI3K alpha (Canis familiaris)
• G alpha (q) inhibits PI3K alpha (Danio rerio)
• G alpha (q) inhibits PI3K alpha (Gallus gallus)
• G alpha (q) inhibits PI3K alpha (Mus musculus)
• G alpha (q) inhibits PI3K alpha (Rattus norvegicus)
• G alpha (q) inhibits PI3K alpha (Sus scrofa)
• G alpha (q) inhibits PI3K alpha (Taeniopygia guttata)
• G alpha (q) inhibits PI3K alpha (Xenopus tropicalis)