Reactome | FPR2 [plasma membrane]

FPR2 [plasma membrane]

Stable Identifier

R-HSA-416408

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FPRL1, LXA4 receptor, N-formyl peptide receptor 2, FPR2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
        
        FPR2 binds FPR2 ligands (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)
        
        FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
        
        FPR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25090 FPR2

Gene Names

FPR2, FPRH1, FPRL1, LXA4R

Chain

chain:1-351

Reference Genes

BioGPS Gene:2358 FPR2

COSMIC (genes):FPR2 FPR2

CTD Gene:2358 FPR2

dbSNP Gene:2358 FPR2

ENSEMBL:ENSG00000171049 FPR2

HGNC:3827 FPR2

KEGG:hsa:2358 FPR2

Monarch:2358 FPR2

NCBI Gene:2358 FPR2

OMIM:136538 FPR2

UCSC:P25090 FPR2

Reference Transcript

Other Identifiers

11734034_a_at

11734035_a_at

11739140_a_at

16864751

210772_PM_at

210772_at

210773_PM_s_at

210773_s_at

2358

37095_r_at

3839911

3839912

3839914

3839915

3839916

3839917

8030860

A_14_P200556

A_23_P55649

D10922_s_at

GE88015

GO:0001540

GO:0001774

GO:0002376

GO:0002430

GO:0002768

GO:0004875

GO:0004930

GO:0004982

GO:0005124

GO:0005515

GO:0005737

GO:0005886

GO:0006898

GO:0006935

GO:0006954

GO:0007155

GO:0007165

GO:0007166

GO:0007186

GO:0007193

GO:0007200

GO:0007204

GO:0016020

GO:0016192

GO:0019722

GO:0032930

GO:0035579

GO:0038023

GO:0038024

GO:0042742

GO:0045089

GO:0048143

GO:0050728

GO:0050766

GO:0050918

GO:0060089

GO:0070374

GO:0070821

GO:0090026

GO:0098542

GO:0101003

GO:1904646

HMNXSV003033568

ILMN_1740875

ILMN_2392569

PH_hs_0029057

PH_hs_0031471

TC19000788.hg

g1916075_3p_a_at

Participates

as a member of

as an input of

FPR2 binds FPR2 ligands (Homo sapiens)

as a component of

FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)

Other forms of this molecule

FPR2 [ficolin-1-rich granule membrane]

FPR2 [specific granule membrane]

FPR2 [tertiary granule membrane]

Inferred To

LOC100491504 [plasma membrane] (Xenopus tropicalis)

Fpr2 [plasma membrane] (Mus musculus)

Fpr2 [plasma membrane] (Rattus norvegicus)

FPR2 [plasma membrane] (Canis familiaris)

Cross References

RefSeq

XP_016882031.1, NP_001005738.1, XP_006723183.1, NP_001453.1

Guide to Pharmacology - Targets

223

OpenTargets

ENSG00000171049

ENSEMBL

ENST00000598776, ENST00000598953, ENST00000340023, ENSP00000468876, ENSP00000340191, ENSP00000468897

ZINC - Substances

FPR2_HUMAN

ZINC target

P25090

PRO

P25090

GlyGen

P25090

PDB

7T6S, 6LW5, 7WVW, 7WVY, 7WVX, 7WVV, 6OMM, 7T6U, 7T6V

HPA

ENSG00000171049-FPR2

Pharos - Targets

P25090

ZINC - Predictions - Purchasable

FPR2_HUMAN

HMDB Protein

HMDBP02158

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q8N386 LRC25			0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:O75110 ATP9A	1	ATP9A [plasma membrane] (R-HSA-939754)	0.527	2
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [secretory granule membrane] (R-HSA-437105) SLC30A5 [Golgi membrane] (R-HSA-9817559)	0.527	3
UniProt:O95427 PIGN	1	PIGN [endoplasmic reticulum membrane] (R-HSA-162724)	0.527	2
UniProt:Q9NXB9 ELOVL2	1	ELOVL2 [endoplasmic reticulum membrane] (R-HSA-548677)	0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.527	2
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.527	3
UniProt:Q8TDW0 LRRC8C	1	LRRC8C [plasma membrane] (R-HSA-8941519)	0.527	2
UniProt:Q6ZMG9 CERS6	1	CERS6 [endoplasmic reticulum membrane] (R-HSA-428145)	0.527	3
UniProt:O43760 SNG2			0.527	2
UniProt:Q99808 SLC29A1	1	SLC29A1 [plasma membrane] (R-HSA-54335)	0.527	3
UniProt:Q6NZ67 MZT2B	1	MZT2B [cytosol] (R-HSA-8955057)	0.527	2
UniProt:Q9NR77 PXMP2	2	PXMP2 [cytosol] (R-HSA-9603794) PXMP2 [peroxisomal membrane] (R-HSA-8953432)	0.527	2
UniProt:Q3SXM5 HSDL1			0.527	2
UniProt:Q8N6M3 FITM2	1	FITM2 [endoplasmic reticulum membrane] (R-HSA-8857678)	0.527	2
UniProt:Q8N5B7 CERS5	1	CERS5 [endoplasmic reticulum membrane] (R-HSA-428168)	0.527	2
UniProt:Q5BKT4 ALG10	1	ALG10 [endoplasmic reticulum membrane] (R-HSA-449650)	0.527	2
UniProt:Q8N8J7 F241A			0.527	2
UniProt:Q6N075 MFSD5			0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:Q15155 NOMO1			0.527	3
UniProt:Q96JG6 VPS50			0.527	2
UniProt:Q8NHP6 MOSPD2	3	MOSPD2 [endosome membrane] (R-HSA-9715095) MOSPD2 [plasma membrane] (R-HSA-6806308) MOSPD2 [specific granule membrane] (R-HSA-6799635)	0.527	2
UniProt:Q68DH5 LMBD2			0.527	2
UniProt:P69849 NOMO3			0.527	3
UniProt:Q9BWH2 FUND2			0.527	2
UniProt:Q6Y1H2 HACD2	1	PTPLB [endoplasmic reticulum membrane] (R-HSA-5676075)	0.527	2
UniProt:P03928 MT-ATP8	1	MT-ATP8 [mitochondrial inner membrane] (R-HSA-50500)	0.527	2
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.527	2
UniProt:Q8WUD6 CHPT1	1	CHPT1 [Golgi membrane] (R-HSA-1498754)	0.527	2
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.527	2
UniProt:Q8NHS3 MFSD8			0.527	2
UniProt:Q7Z3F1 LYCHS			0.527	3
UniProt:Q96HR9 REEP6			0.527	3
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	3
UniProt:Q00765 REEP5			0.527	3
UniProt:Q9NWS8 RMND1			0.527	2
UniProt:Q15041 AR6P1			0.527	2

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