Reactome | GPR17 [plasma membrane]

GPR17 [plasma membrane]

Stable Identifier

R-HSA-416429

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Uracil nucleotide/cysteinyl leukotriene receptor, GPR17_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NU22 MDN1

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External Reference Information

External Reference

UniProt:Q13304 GPR17

Gene Names

GPR17

Chain

chain:1-367

Reference Genes

BioGPS Gene:2840 GPR17

COSMIC (genes):GPR17 GPR17

CTD Gene:2840 GPR17

dbSNP Gene:2840 GPR17

ENSEMBL:ENSG00000144230 GPR17

HGNC:4471 GPR17

KEGG:hsa:2840 GPR17

Monarch:2840 GPR17

NCBI Gene:2840 GPR17

OMIM:603071 GPR17

UCSC:Q13304 GPR17

Reference Transcript

Participates

as an input of

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

Inferred To

Gpr17 [plasma membrane] (Mus musculus)

Gpr17 [plasma membrane] (Rattus norvegicus)

GPR17 [plasma membrane] (Bos taurus)

GPR17 [plasma membrane] (Canis familiaris)

GPR17 [plasma membrane] (Sus scrofa)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016859322.1, NP_005282.1, NP_001154889.1, NP_001154887.1, NP_001154888.1

ZINC - World Drugs

GPR17_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000144230

ENSEMBL

ENSP00000272644, ENSG00000144230, ENST00000544369, ENST00000272644, ENSP00000376741, ENST00000393018, ENSP00000442982, ENSP00000508383, ENST00000486700

ZINC - FDA approved

GPR17_HUMAN

ZINC - Substances

GPR17_HUMAN

ZINC - Biogenic

GPR17_HUMAN

ZINC target

Q13304

PRO

Q13304

GlyGen

Q13304

PDB

7Y89

ZINC - Investigational

GPR17_HUMAN

ZINC - Metabolites

GPR17_HUMAN

GeneCards

GPR17

HPA

ENSG00000144230-GPR17

Pharos - Targets

Q13304

ZINC - Predictions - Purchasable

GPR17_HUMAN

HMDB Protein

HMDBP10776

Interactors (69)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NWS8 RMND1			0.527	2
UniProt:Q7Z333 SETX			0.527	2
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.527	2
UniProt:Q9NZ08 ERAP1	1	ERAP1 [endoplasmic reticulum lumen] (R-HSA-947609)	0.527	2
UniProt:P57678 GEMIN4	2	GEMIN4 [nucleoplasm] (R-HSA-191841) GEMIN4 [cytosol] (R-HSA-191836)	0.527	3
UniProt:Q9NU22 MDN1			0.527	2
UniProt:Q9H0H0 INTS2	1	INTS2 [nucleoplasm] (R-HSA-6807448)	0.527	2
UniProt:Q5H8A4 PIGG	1	PIGG [endoplasmic reticulum membrane] (R-HSA-162716)	0.527	3
UniProt:Q9UI12 ATP6V1H	2	ATP6V1H [cytosol] (R-HSA-167578) ATP6V1H [plasma membrane] (R-HSA-167602)	0.527	2
UniProt:Q5TH69 BIG3			0.527	2
UniProt:Q9H9E3 COG4	2	COG4 [trans-Golgi network membrane] (R-HSA-6813868) COG4 [Golgi membrane] (R-HSA-6808722)	0.527	2
UniProt:Q96JI7 SPTCS			0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	2
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	2
UniProt:Q8NBN3 TMEM87A	1	TMEM87A [endoplasmic reticulum membrane] (R-HSA-9714348)	0.527	2
UniProt:Q7RTS9 DYM			0.527	3
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.527	2
UniProt:Q9H7F0 AT133			0.527	3
UniProt:Q6ZT21 TMPPE			0.527	2
UniProt:Q9Y5L0 TNPO3			0.527	3
UniProt:Q6NZ67 MZT2B	1	MZT2B [cytosol] (R-HSA-8955057)	0.527	2
UniProt:Q9UI26 IPO11			0.527	3
UniProt:Q9BUK6 MSTO1			0.527	2
UniProt:Q8IZQ1 WDFY3			0.527	2
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.527	3
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.527	2
UniProt:O00400 SLC33A1	4	SLC33A1 A110P [Golgi membrane] (R-HSA-5649754) SLC33A1 S113R [Golgi membrane] (R-HSA-5649751) SLC33A1 Y366* [Golgi membrane] (R-HSA-5649750) SLC33A1 [Golgi membrane] (R-HSA-727745)	0.527	2
UniProt:Q6YHU6 THADA	1	THADA [cytoplasm] (R-HSA-8870282)	0.527	3
UniProt:Q9NSG2 FIRRM	4	FIRRM [nucleoplasm] (R-HSA-9853387) p-S43-FIRRM [cytosol] (R-HSA-9851990) p-S43,S744-FIRRM [cytosol] (R-HSA-9853437) FIRRM [cytosol] (R-HSA-9851948)	0.527	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.527	2
UniProt:O15360 FANCA	2	FANCA [nucleoplasm] (R-HSA-419541) FANCA [cytosol] (R-HSA-420796)	0.527	2
UniProt:Q9NV70 EXOC1	2	EXOC1 [plasma membrane] (R-HSA-2872284) EXOC1 [cytosol] (R-HSA-5623375)	0.527	2
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.527	2
UniProt:Q86WJ1 CHD1L	1	CHD1L [nucleoplasm] (R-HSA-5688916)	0.527	2
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.527	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.527	2
UniProt:Q9BXW9 FANCD2	3	MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522)	0.527	3
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:P04035 HMGCR	1	HMGCR [endoplasmic reticulum membrane] (R-HSA-9621345)	0.527	2
UniProt:O60287 NPA1P			0.527	2
UniProt:O94829 IPO13			0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:Q68E01 INTS3	1	INTS3 [nucleoplasm] (R-HSA-6807435)	0.527	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.527	2
UniProt:O14981 BTAF1			0.527	2
UniProt:Q9UFG5 CS025			0.527	2
UniProt:Q86Y56 DAAF5			0.527	3
UniProt:P50748 KNTC1	1	KNTC1 [cytosol] (R-HSA-376233)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.527	2
UniProt:Q9Y6D6 BIG1			0.527	2
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	3
UniProt:O43156 TTI1			0.527	3
UniProt:Q9NZJ4 SACS			0.527	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.527	2
UniProt:Q9UPN7 PPP6R1	1	PPP6R1 [cytosol] (R-HSA-5685721)	0.527	2
UniProt:Q6ZT12 UBR3			0.527	2
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:Q5VST6 ABHD17B	1	ABHD17B [plasma membrane] (R-HSA-9647770)	0.527	3
UniProt:Q29RF7 PDS5A	4	PDS5A [nucleoplasm] (R-HSA-2468043) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [chromosome] (R-HSA-2466360) PDS5A [cytosol] (R-HSA-2484799)	0.527	2
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	2
UniProt:Q96ED9 HOOK2			0.527	2
UniProt:Q8TBA6 GOLGA5	2	GOLGA5 [transport vesicle] (R-HSA-8847517) GOLGA5 [Golgi membrane] (R-HSA-8847514)	0.527	2
UniProt:Q96HA7 TONSL			0.527	2
UniProt:Q5W0V3 FHI2A			0.527	2
UniProt:O43264 ZW10	1	ZW10 [cytosol] (R-HSA-377880)	0.527	2
UniProt:Q5HYK3 COQ5	1	COQ5 [mitochondrial matrix] (R-HSA-2162210)	0.527	2

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