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GRK5 [plasma membrane]
Stable Identifier
R-HSA-416468
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G protein-coupled receptor kinase 5, GRK5_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
GRK5 sequesters activated Gq (Homo sapiens)
G-protein alpha (q):GRK5 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)
ADRB2:Catecholamine:GRK [plasma membrane] (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
pS-ADRB2:Catecholamine:GRK [plasma membrane] (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
GRKs bind ADRB2:Catecholamine (Homo sapiens)
ADRB2:Catecholamine:GRK [plasma membrane] (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
GRK5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34947 GRK5
Gene Names
GRK5, GPRK5
Chain
chain:1-590
Reference Genes
BioGPS Gene:2869 GRK5
COSMIC (genes):GRK5 GRK5
CTD Gene:2869 GRK5
dbSNP Gene:2869 GRK5
ENSEMBL:ENSG00000198873 GRK5
ENSEMBL_homo_sapiens_GENE:ENSG00000198873.12 GRK5
HGNC:4544 GRK5
KEGG Gene (Homo sapiens):2869 GRK5
Monarch:2869 GRK5
NCBI Gene:2869 GRK5
OMIM:600870 GRK5
UCSC:P34947 GRK5
Reference Transcript
RefSeq:NM_005308.2 GRK5
Other Identifiers
1135_at
11729227_a_at
11729228_a_at
11747250_a_at
11760784_at
11760785_s_at
1557729_PM_at
1557729_at
16709822
204395_PM_s_at
204395_s_at
204396_PM_s_at
204396_s_at
2869
3267037
3267038
3267039
3267040
3267058
3267070
3267072
3267083
3267084
3267085
3267086
3267087
3267088
3267089
3267090
3267095
3267097
3267098
3267100
3267101
3267102
3267103
3267104
3267105
3267106
3267107
3267108
3267109
3267274
3267275
3267276
40994_at
7930894
7930917
A_33_P3244640
GE555705
GE62554
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004703
GO:0005080
GO:0005515
GO:0005524
GO:0005543
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006915
GO:0007165
GO:0007186
GO:0007188
GO:0007217
GO:0008277
GO:0008284
GO:0008289
GO:0009966
GO:0012501
GO:0016020
GO:0016055
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0023052
GO:0030154
GO:0031965
GO:0036211
GO:0043066
GO:0043226
GO:0045444
GO:0046777
GO:0047696
GO:0051726
GO:0140096
HMNXSV003012390
HMNXSV003053987
Hs.211569.0.A1_3p_a_at
Hs2.375498.1.A1_3p_at
ILMN_1728830
ILMN_2096719
L15388_at
PH_hs_0012265
PH_hs_0018237
PH_hs_0032185
TC10000865.hg
g4885348_3p_a_at
Participates
as a member of
GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)
as a component of
G-protein alpha (q):GRK5 [plasma membrane] (Homo sapiens)
as an input of
GRK5 sequesters activated Gq (Homo sapiens)
Inferred To
GRK5 [plasma membrane]
(Bos taurus)
GRK5 [plasma membrane]
(Canis familiaris)
GRK5 [plasma membrane]
(Drosophila melanogaster)
GRK5 [plasma membrane]
(Gallus gallus)
GRK5 [plasma membrane]
(Mus musculus)
GRK5 [plasma membrane]
(Rattus norvegicus)
GRK5 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_005299.1
Guide to Pharmacology - Targets
1469
OpenTargets
ENSG00000198873
ZINC - Substances
GRK5_HUMAN
ZINC target
P34947
ZINC - Biogenic
GRK5_HUMAN
PRO
P34947
PDB
4TND
,
8UAP
,
6PJX
,
8UAQ
,
4TNB
IntEnz
2.7.11.16
GeneCards
P34947
HPA
ENSG00000198873-GRK5
Ensembl
ENSP00000376609
,
ENSG00000198873
,
ENST00000392870
Pharos - Targets
P34947
ZINC - Predictions - Purchasable
GRK5_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97288
1
Htr4 [plasma membrane]
(R-MMU-391008)
0.632
8
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.558
2
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