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G alpha (12/13) signalling events
Stable Identifier
R-HSA-416482
Type
Pathway
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
General
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The G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay technologies that measure intracellular calcium. The G12/13 family are best known for their involvement in the processes of cell proliferation and morphology, such as stress fiber and focal adhesion formation. Interactions with Rho guanine nucleotide exchange factors (RhoGEFs) are thought to mediate many of these processes. (Buhl et al.1995, Sugimoto et al. 2003). Activation of Rho or the regulation of events through Rho is often taken as evidence of G12/13 signaling. Receptors that are coupled with G12/13 invariably couple with one or more other G protein subtypes, usually Gq.
Literature References
PubMed ID
Title
Journal
Year
19212140
Regulation and physiological functions of G12/13-mediated signaling pathways
Kozasa, T
,
Suzuki, N
,
Hajicek, N
Neurosignals
2009
18814923
G(12)/G(13)-mediated signalling in mammalian physiology and disease
Offermanns, S
,
Worzfeld, T
,
Wettschureck, N
Trends Pharmacol Sci
2008
Participants
Events
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
(Homo sapiens)
Liganded G12/13-activating GPCR acts as a GEF for G12/13
(Homo sapiens)
The Ligand:GPCR:G12/13 complex dissociates
(Homo sapiens)
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
(Homo sapiens)
p115-RhoGEF activation of RHOA
(Homo sapiens)
GEFs activate RhoA,B,C
(Homo sapiens)
ROCK activation by RHO
(Homo sapiens)
ROCK1,2 bind ROCKi
(Homo sapiens)
LARG activation by G alpha 12/13
(Homo sapiens)
LARG binds plexin B1
(Homo sapiens)
G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
(Homo sapiens)
Inactive G alpha (12/13) reassociates with G beta:gamma
(Homo sapiens)
G alpha (12) binds BTK
(Homo sapiens)
BTK in G alpha (12)-BTK complex is activated
(Homo sapiens)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)
(Homo sapiens)
Participates
as an event of
GPCR downstream signalling (Homo sapiens)
Orthologous Events
G alpha (12/13) signalling events (Bos taurus)
G alpha (12/13) signalling events (Caenorhabditis elegans)
G alpha (12/13) signalling events (Canis familiaris)
G alpha (12/13) signalling events (Danio rerio)
G alpha (12/13) signalling events (Dictyostelium discoideum)
G alpha (12/13) signalling events (Drosophila melanogaster)
G alpha (12/13) signalling events (Gallus gallus)
G alpha (12/13) signalling events (Mus musculus)
G alpha (12/13) signalling events (Rattus norvegicus)
G alpha (12/13) signalling events (Saccharomyces cerevisiae)
G alpha (12/13) signalling events (Schizosaccharomyces pombe)
G alpha (12/13) signalling events (Sus scrofa)
G alpha (12/13) signalling events (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000088
Authored
Jupe, S (2009-03-18)
Reviewed
Akkerman, JW (2009-06-03)
Created
Jupe, S (2009-03-27)
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