G alpha (12/13) signalling events

Stable Identifier
R-HSA-416482
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay technologies that measure intracellular calcium. The G12/13 family are best known for their involvement in the processes of cell proliferation and morphology, such as stress fiber and focal adhesion formation. Interactions with Rho guanine nucleotide exchange factors (RhoGEFs) are thought to mediate many of these processes. (Buhl et al.1995, Sugimoto et al. 2003). Activation of Rho or the regulation of events through Rho is often taken as evidence of G12/13 signaling. Receptors that are coupled with G12/13 invariably couple with one or more other G protein subtypes, usually Gq.

Literature References
PubMed ID Title Journal Year
19212140 Regulation and physiological functions of G12/13-mediated signaling pathways

Suzuki, N, Hajicek, N, Kozasa, T

Neurosignals 2009
18814923 G(12)/G(13)-mediated signalling in mammalian physiology and disease

Worzfeld, T, Wettschureck, N, Offermanns, S

Trends Pharmacol Sci 2008
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
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Reviewed
Created