GRK5 sequesters activated Gq

Stable Identifier
R-HSA-416510
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells.

Literature References
PubMed ID Title Journal Year
10861009 G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells Proc Natl Acad Sci U S A 2000
Participants
Participant Of
Inferred From