Reactome: A Curated Pathway Database

GRK5 sequesters activated Gq

Stable Identifier
R-HSA-416510
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Inferred From