GRK5 sequesters activated Gq

Stable Identifier
R-HSA-416510
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GRKs are serine/threonine kinases that phosphorylate GPCRs leading to receptor desensitization. GRK5 appears to be the predominant regulator of PAR1 desensitization in endothelial cells.

Literature References
PubMed ID Title Journal Year
10861009 G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

Tiruppathi, C, Yan, W, Sandoval, R, Naqvi, T, Pronin, AN, Benovic, JL, Malik, AB

Proc Natl Acad Sci U S A 2000
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