GRK2 sequesters activated Gq

Stable Identifier
R-HSA-416516
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

GRK2 can inhibit GPCR signaling via phosphorylation-independent sequestration of Gq/11/14 subunits utilising its RGS homology (RH) domain. GRK2 may be an effector of activated Gq, initiating signalling cascades other than the classical PLC beta signalling associated with Gq.

Literature References
PubMed ID Title Journal Year
10727532 Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq

Sallese, M, Mariggiò, S, D'Urbano, E, Iacovelli, L, De Blasi, A

Mol. Pharmacol. 2000
16339447 Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex

Tesmer, VM, Kawano, T, Shankaranarayanan, A, Kozasa, T, Tesmer, JJ

Science 2005
10567430 Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

Carman, CV, Parent, JL, Day, PW, Pronin, AN, Sternweis, PM, Wedegaertner, PB, Gilman, AG, Benovic, JL, Kozasa, T

J Biol Chem 1999
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