GRK2 sequesters activated Gq

Stable Identifier
R-HSA-416516
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GRK2 can inhibit GPCR signaling via phosphorylation-independent sequestration of Gq/11/14 subunits utilising its RGS homology (RH) domain. GRK2 may be an effector of activated Gq, initiating signalling cascades other than the classical PLC beta signalling associated with Gq.

Participants
Participant Of
Orthologous Events