Sema4D mediated inhibition of cell attachment and migration

Stable Identifier
R-HSA-416550
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.

Literature References
PubMed ID Title Journal Year
16314868 Semaphorins command cells to move

Kruger, RP, Aurandt, J, Guan, KL

Nat Rev Mol Cell Biol 2005
14770294 Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D

Kumanogoh, A, Kikutani, H

Cell Mol Life Sci 2004
18374575 Semaphorin signaling: progress made and promises ahead

Zhou, Y, Gunput, RA, Pasterkamp, RJ

Trends Biochem Sci 2008
Participants
Participant Of
Orthologous Events
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Reviewed