Sema4D induced cell migration and growth-cone collapse

Stable Identifier
R-HSA-416572
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Sema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates MLC to induce actomyosin stress fiber contraction and to direct the assembly of focal adhesion complexes and integrin-mediated adhesion.

Literature References
PubMed ID Title Journal Year
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

Swiercz, JM, Kuner, R, Offermanns, S

J Cell Biol 2004
15818466 Plexins: axon guidance and signal transduction

Negishi, M, Oinuma, I, Katoh, H

Cell Mol Life Sci 2005
18374575 Semaphorin signaling: progress made and promises ahead

Zhou, Y, Gunput, RA, Pasterkamp, RJ

Trends Biochem Sci 2008
12220504 Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

Hirotani, M, Ohoka, Y, Yamamoto, T, Nirasawa, H, Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S

Biochem Biophys Res Commun 2002
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed
Created