Reactome | Sema4D induced cell migration and growth-cone collapse

Sema4D induced cell migration and growth-cone collapse

Stable Identifier

R-HSA-416572

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Sema4D induced cell migration and growth-cone collapse

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Sema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates MLC to induce actomyosin stress fiber contraction and to direct the assembly of focal adhesion complexes and integrin-mediated adhesion.

Literature References

PubMed ID	Title	Journal	Year
15818466	Plexins: axon guidance and signal transduction Negishi, M, Oinuma, I, Katoh, H	Cell Mol Life Sci	2005
15210733	Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 Swiercz, JM, Kuner, R, Offermanns, S	J Cell Biol	2004
18374575	Semaphorin signaling: progress made and promises ahead Zhou, Y, Gunput, RA, Pasterkamp, RJ	Trends Biochem Sci	2008
12220504	Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors Hirotani, M, Ohoka, Y, Yamamoto, T, Nirasawa, H, Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S	Biochem Biophys Res Commun	2002