Sema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates MLC to induce actomyosin stress fiber contraction and to direct the assembly of focal adhesion complexes and integrin-mediated adhesion.
Zhou, Y, Pasterkamp, RJ, Gunput, RA
Katoh, H, Oinuma, I, Negishi, M
Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S, Yamamoto, T, Hirotani, M, Ohoka, Y, Nirasawa, H
Offermanns, S, Kuner, R, Swiercz, JM
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