Activation of Rho by LARG and PDZ-RhoGEF

Stable Identifier
R-HSA-416588
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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The RhoGEFs LARG and PDZ-RhoGEF complexed with Plexin-B1 stimulate the exchange of GDP for GTP on RhoA through their DH and PH domains.
Literature References
PubMed ID Title Journal Year
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

Offermanns, S, Kuner, R, Swiercz, JM

J Cell Biol 2004
12730235 Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

Katoh, H, Oinuma, I, Negishi, M, Harada, A

J Biol Chem 2003
12220504 Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S, Yamamoto, T, Hirotani, M, Ohoka, Y, Nirasawa, H

Biochem Biophys Res Commun 2002
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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