Reactome | LARG and PDZ-RhoGEF binds to Plexin-B1

LARG and PDZ-RhoGEF binds to Plexin-B1

Stable Identifier

R-HSA-416594

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)

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Plexin-B1 activates RhoA and induces growth cone collapse and and cytoskeletal reorganization through Rho-specific guanine nucleotide exchange factors PDZ-RhoGEF (ARHGEF11) and leukemia-associated RhoGEF (LARG, ARHGEF12). Plexin-B1 directly interacts with PDZ-RhoGEF through its c-terminal PDZ domain binding motif. It has been suggested that Rnd1, which binds to the cytoplasmic part of plexin-B1, can promote the interaction between plexin-B1 and PDZ-RhoGEF. The PDZ domain of LARG is directly involved in the interaction with the c-terminal sequence of Plexin-B1.

Literature References

PubMed ID	Title	Journal	Year
12196628	The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG Guan, KL, Vikis, HG, Aurandt, J, Ahn, N, Gutkind, JS	Proc Natl Acad Sci U S A	2002
15210733	Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 Offermanns, S, Kuner, R, Swiercz, JM	J Cell Biol	2004
12730235	Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells Katoh, H, Oinuma, I, Negishi, M, Harada, A	J Biol Chem	2003
12220504	Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S, Yamamoto, T, Hirotani, M, Ohoka, Y, Nirasawa, H	Biochem Biophys Res Commun	2002