LARG and PDZ-RhoGEF binds to Plexin-B1

Stable Identifier
R-HSA-416594
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Plexin-B1 activates RhoA and induces growth cone collapse and and cytoskeletal reorganization through Rho-specific guanine nucleotide exchange factors PDZ-RhoGEF (ARHGEF11) and leukemia-associated RhoGEF (LARG, ARHGEF12). Plexin-B1 directly interacts with PDZ-RhoGEF through its c-terminal PDZ domain binding motif. It has been suggested that Rnd1, which binds to the cytoplasmic part of plexin-B1, can promote the interaction between plexin-B1 and PDZ-RhoGEF. The PDZ domain of LARG is directly involved in the interaction with the c-terminal sequence of Plexin-B1.

Literature References
PubMed ID Title Journal Year
15210733 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

Swiercz, JM, Kuner, R, Offermanns, S

J Cell Biol 2004
12196628 The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

Aurandt, J, Vikis, HG, Gutkind, JS, Ahn, N, Guan, KL

Proc Natl Acad Sci U S A 2002
12730235 Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

Oinuma, I, Katoh, H, Harada, A, Negishi, M

J Biol Chem 2003
12220504 Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

Hirotani, M, Ohoka, Y, Yamamoto, T, Nirasawa, H, Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S

Biochem Biophys Res Commun 2002
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