Reactome | COPS6 [cytosol]

COPS6 [cytosol]

Stable Identifier

R-HSA-416961

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

COP9 signalosome complex subunit 6, CSN6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7L5N1 COPS6

Gene Names

COPS6, CSN6, HVIP

Chain

chain:1-327

Reference Genes

BioGPS Gene:10980 COPS6

COSMIC (genes):COPS6 COPS6

CTD Gene:10980 COPS6

dbSNP Gene:10980 COPS6

ENSEMBL:ENSG00000168090 COPS6

ENSEMBL_homo_sapiens_GENE:ENSG00000168090.10 COPS6

HGNC:21749 COPS6

KEGG Gene (Homo sapiens):10980 COPS6

Monarch:10980 COPS6

NCBI Gene:10980 COPS6

OMIM:614729 COPS6

UCSC:Q7L5N1 COPS6

Reference Transcript

RefSeq:NM_006833.4 COPS6

Other Identifiers

10980

11757481_a_at

17049103

201405_PM_s_at

201405_s_at

213504_PM_at

213504_at

3015217

3015218

3015219

3015221

3015224

3015226

3015228

3015230

3015232

3015233

3015235

3015236

3015237

3015238

40138_at

8134699

A_23_P8432

GE81686

GE86282

GO:0000338

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0008180

GO:0008233

GO:0008237

GO:0016787

GO:0036211

GO:0043226

GO:0045116

GO:0048471

GO:0140096

GO:2000434

HMNXSV003029168

Hs.15591.1.S1_3p_at

ILMN_1764431

PH_hs_0040240

TC07000609.hg

U70735_at

g5803095_3p_a_at

Participates

as a component of

COP9 [cytosol] (Homo sapiens)

Other forms of this molecule

COPS6 [nucleoplasm]

Inferred To

CSN6 [cytosol] (Drosophila melanogaster)

Cops6 [cytosol] (Mus musculus)

Cops6 [cytosol] (Rattus norvegicus)

COPS6 [cytosol] (Bos taurus)

COPS6 [cytosol] (Canis familiaris)

COPS6 [cytosol] (Sus scrofa)

Ghost homologue of COPS6 [cytosol] (Danio rerio)

Ghost homologue of COPS6 [cytosol] (Gallus gallus)

csn-6 [cytosol] (Caenorhabditis elegans)

cops6 [cytosol] (Xenopus tropicalis)

csn6 [cytosol] (Dictyostelium discoideum)

Homologues of COPS6 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006824.2

OpenTargets

ENSG00000168090

GeneCards

Q7L5N1

HPA

ENSG00000168090-COPS6

Ensembl

ENST00000303904, ENSP00000304102, ENSG00000168090

PRO

Q7L5N1

Pharos - Targets

Q7L5N1

PDB

4D10, 4D18, 6R7H, 6R7I, 6R7F, 8H3F, 8H3A, 4QFT, 4WSN, 6R6H, 4R14, 8H38

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.725	7
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.725	8
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.653	7
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.648	4
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.643	3
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.643	6
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.643	8
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.597	11
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.564	2
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.544	2
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	4
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.527	2
UniProt:Q15048 LRRC14	1	LRRC14 [cytosol] (R-HSA-9749455)	0.527	5
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.527	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	8
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.527	3
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.527	5
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.527	3
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [nucleoplasm] (R-HSA-349450) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [cytosol] (R-HSA-349439)	0.525	3

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