Reactome | COPS5 [cytosol]

COPS5 [cytosol]

Stable Identifier

R-HSA-416963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

COP9 signalosome complex subunit 5, CSN5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92905 COPS5

Gene Names

COPS5, CSN5, JAB1

Chain

initiator methionine:, chain:2-334

Reference Genes

BioGPS Gene:10987 COPS5

COSMIC (genes):COPS5 COPS5

CTD Gene:10987 COPS5

dbSNP Gene:10987 COPS5

ENSEMBL:ENSG00000121022 COPS5

ENSEMBL_homo_sapiens_GENE:ENSG00000121022.14 COPS5

HGNC:2240 COPS5

KEGG Gene (Homo sapiens):10987 COPS5

Monarch:10987 COPS5

NCBI Gene:10987 COPS5

OMIM:604850 COPS5

UCSC:Q92905 COPS5

Reference Transcript

RefSeq:NM_006837.2 COPS5

Other Identifiers

10987

11721461_a_at

11754844_x_at

1789_at

201652_PM_at

201652_at

3138979

3138980

3138981

3138985

3138990

3138992

3138993

3138994

3138995

3138996

3139002

3139003

3139004

3139005

3139006

8151136

A_23_P71419

GE62793

GO:0000338

GO:0000785

GO:0003713

GO:0003743

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005852

GO:0006351

GO:0006355

GO:0006412

GO:0006413

GO:0006508

GO:0008021

GO:0008180

GO:0008233

GO:0008237

GO:0012501

GO:0016192

GO:0016579

GO:0016787

GO:0019784

GO:0019899

GO:0023052

GO:0031410

GO:0035718

GO:0036211

GO:0043066

GO:0043226

GO:0043687

GO:0045116

GO:0045182

GO:0045202

GO:0045944

GO:0046328

GO:0046872

GO:0048471

GO:0051091

GO:0051726

GO:0140096

GO:0140110

GO:0140492

GO:1903894

GO:1990182

GO:2000434

HMNXSV003027773

ILMN_1736002

PH_hs_0030317

U65928_at

g5803045_3p_at

Participates

as a component of

COP9 [cytosol] (Homo sapiens)

Other forms of this molecule

COPS5 [nucleoplasm]

Inferred To

COPS5 [cytosol] (Bos taurus)

COPS5 [cytosol] (Caenorhabditis elegans)

COPS5 [cytosol] (Canis familiaris)

COPS5 [cytosol] (Danio rerio)

COPS5 [cytosol] (Dictyostelium discoideum)

COPS5 [cytosol] (Drosophila melanogaster)

COPS5 [cytosol] (Gallus gallus)

COPS5 [cytosol] (Mus musculus)

COPS5 [cytosol] (Sus scrofa)

COPS5 [cytosol] (Xenopus tropicalis)

Cops5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006828.2

OpenTargets

ENSG00000121022

HPA

ENSG00000121022-COPS5

GeneCards

Q92905

Ensembl

ENSG00000121022, ENSP00000350512, ENST00000357849

PRO

Q92905

Pharos - Targets

Q92905

PDB

8H38, 4F7O, 5JOG, 6R7F, 6R7I, 4D18, 8H3A, 6R6H, 4D10, 4WSN, 5M5Q, 6R7H, 5JOH, 8H3F

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.837	10
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.736	9
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.723	14
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.643	4
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.639	10
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.602	3
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.593	3
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.593	4
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	5
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.553	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.553	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.547	2
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.547	2
UniProt:Q9NSI6 BRWD1	1	BRWD1 [nucleoplasm] (R-HSA-8863306)	0.547	2
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.528	2
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.527	3
UniProt:Q15048 LRRC14	1	LRRC14 [cytosol] (R-HSA-9749455)	0.527	3
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	6
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.462	2

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