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COPS4 [cytosol]
Stable Identifier
R-HSA-416965
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
COP9 signalosome complex subunit 4, CSN4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB1 GTPase cycle (Homo sapiens)
RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
COP9 and TOR1 deneddylate STON2 (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
NEDD8-STONs:TOR1 hexamer:COP9 [cytosol] (Homo sapiens)
COP9 [cytosol] (Homo sapiens)
COPS4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BT78 COPS4
Gene Names
COPS4, CSN4
Chain
initiator methionine:, chain:2-406
Reference Genes
BioGPS Gene:51138 COPS4
COSMIC (genes):COPS4 COPS4
CTD Gene:51138 COPS4
dbSNP Gene:51138 COPS4
ENSEMBL:ENSG00000138663 COPS4
HGNC:16702 COPS4
KEGG:hsa:51138 COPS4
Monarch:51138 COPS4
NCBI Gene:51138 COPS4
OMIM:616008 COPS4
UCSC:Q9BT78 COPS4
Reference Transcript
RefSeq:NM_001258006.1 COPS4
RefSeq:NM_001330727.1 COPS4
RefSeq:NM_016129.2 COPS4
Other Identifiers
11743307_a_at
11743308_s_at
16968407
218042_PM_at
218042_at
2733929
2733930
2733931
2733933
2733934
2733935
2733936
2733937
2733938
2733939
2733942
2733943
2733944
2733945
2733947
2733948
2733949
2733950
2733951
2733952
2733953
2733954
2733955
46232_at
51138
77610_at
8096098
A_14_P105040
A_14_P122108
A_23_P340457
A_23_P43779
GE82082
GO:0000338
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0008021
GO:0008180
GO:0016607
GO:0016787
GO:0019784
GO:0030054
GO:0031410
GO:0032991
GO:0043226
GO:0045116
GO:0045202
GO:0140096
GO:2000434
HMNXSV003024896
ILMN_1726755
PH_hs_0000671
TC04000458.hg
g7705844_3p_at
Participates
as a candidate of
RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
as a component of
COP9 [cytosol] (Homo sapiens)
Other forms of this molecule
COPS4 [nucleoplasm]
Inferred To
COPS4 [cytosol]
(Bos taurus)
COPS4 [cytosol]
(Gallus gallus)
COPS4 [cytosol]
(Sus scrofa)
CSN4 [cytosol]
(Drosophila melanogaster)
Cops4 [cytosol]
(Mus musculus)
Cops4 [cytosol]
(Rattus norvegicus)
csn4 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of COPS4 [cytosol]
(Canis familiaris)
cops4 [cytosol]
(Danio rerio)
cops4 [cytosol]
(Xenopus tropicalis)
csn-4 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_057213.2
,
NP_001317656.1
,
NP_001244935.1
OpenTargets
ENSG00000138663
ENSEMBL
ENST00000264389
,
ENSP00000264389
,
ENSP00000425976
,
ENST00000509093
HPA
ENSG00000138663-COPS4
PRO
Q9BT78
Pharos - Targets
Q9BT78
GlyGen
Q9BT78
PDB
6R7F
,
6R7N
,
8H3F
,
4D0P
,
6R6H
,
4D10
,
6R7I
,
8H3A
,
8H38
,
6R7H
,
4D18
,
4WSN
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.669
4
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
0.643
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P61081 UBE2M
5
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
UBE2M [cytosol]
(R-HSA-947619)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
0.527
2
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.524
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.462
6
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