Reactome | NEDD8 [cytosol]

NEDD8 [cytosol]

Stable Identifier

R-HSA-416969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NEDD8_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15843 NEDD8

Gene Names

NEDD8

Chain

chain:1-76, propeptide:77-81

Reference Genes

BioGPS Gene:4738 NEDD8

COSMIC (genes):NEDD8 NEDD8

CTD Gene:4738 NEDD8

dbSNP Gene:4738 NEDD8

ENSEMBL:ENSG00000129559 NEDD8

ENSEMBL_homo_sapiens_GENE:ENSG00000129559.13 NEDD8

ENSEMBL_homo_sapiens_GENE:ENSG00000285246.2 NEDD8

HGNC:7732 NEDD8

KEGG Gene (Homo sapiens):4738 NEDD8

Monarch:4738 NEDD8

NCBI Gene:4738 NEDD8

OMIM:603171 NEDD8

UCSC:Q15843 NEDD8

Reference Transcript

RefSeq:NM_006156.2 NEDD8

Other Identifiers

11715967_a_at

11715968_s_at

11754081_a_at

11754082_x_at

11757472_x_at

1695_at

201840_PM_at

201840_at

2344451

2344453

3557987

3557988

3557989

3557990

3557993

3557995

3558005

4738

7978201

A_23_P88420

A_24_P301240

D23662_at

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006508

GO:0006511

GO:0008104

GO:0009653

GO:0019941

GO:0030162

GO:0030163

GO:0031386

GO:0031625

GO:0036211

GO:0043226

GO:0045116

GO:0048856

GO:0070062

HMNXSV003034944

ILMN_1785711

PH_hs_0004335

TC14001936.hg

TC14002343.hg

g5453759_3p_at

Participates

as an output of

as a component of

as an input of

as a member of

NEDD8,UBD [cytosol] (Homo sapiens)

as a repeated unit of

monoNEDD8 [cytosol] (Homo sapiens)

Other forms of this molecule

C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]

NEDD8 [nucleoplasm]

C116-AcM-UBE2F-G76-NEDD8 [cytosol]

NEDD8(77-81) [cytosol]

NEDD8(1-81) [cytosol]

C237-UBA3-G76-NEDD8 [cytosol]

C111-AcM-UBE2M-G76-NEDD8 [cytosol]

Inferred To

RUB1 [cytosol] (Saccharomyces cerevisiae)

ubl1 [cytosol] (Schizosaccharomyces pombe)

nedd8 [cytosol] (Dictyostelium discoideum)

nedd8 [cytosol] (Xenopus tropicalis)

ned-8 [cytosol] (Caenorhabditis elegans)

nedd8l [cytosol] (Danio rerio)

NEDD8 [cytosol] (Bos taurus)

NEDD8 [cytosol] (Canis familiaris)

NEDD8 [cytosol] (Gallus gallus)

NEDD8 [cytosol] (Plasmodium falciparum)

NEDD8 [cytosol] (Sus scrofa)

Nedd8 [cytosol] (Drosophila melanogaster)

Nedd8 [cytosol] (Mus musculus)

Nedd8 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006147.1

OpenTargets

ENSG00000129559

GeneCards

Q15843

HPA

ENSG00000129559-NEDD8

Ensembl

ENSG00000129559, ENSG00000285246, ENSP00000250495, ENSP00000496420, ENST00000643069, ENST00000250495

PRO

Q15843

Pharos - Targets

Q15843

PDB

2BKR, 2N7K, 2KO3, 3DQV, 1XT9, 3DBH, 6R7I, 4HCP, 2NVU, 8WQC, 1R4M, 8Q7H, 3DBL, 7ONI, 8RX0, 7B5L, 8B3I, 4FBJ, 8CAF, 3DBR, 4F8C, 3GZN, 6TTU, 1R4N, 6R7F, 8H38, 7B5N, 4P5O, 1NDD, 8WQG

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.961	23
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.936	11
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.802	7
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.725	9
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.723	5
UniProt:O15037 KHNYN			0.698	13
UniProt:Q13564 NAE1	1	NAE1 [cytosol] (R-HSA-8951449)	0.669	7
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.666	4
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.666	4
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.643	5
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.623	3
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.623	3
UniProt:Q13098 GPS1	2	GPS1 [nucleoplasm] (R-HSA-5697010) GPS1 [cytosol] (R-HSA-416972)	0.592	6
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.564	6
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.556	3
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P62266 RPS23	3	3OHP62-RPS23 [nucleoplasm] (R-HSA-9630773) RPS23 [nucleoplasm] (R-HSA-6791209) RPS23 [cytosol] (R-HSA-72353)	0.527	2
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.527	2
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.527	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.527	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:Q53GT1 KLHL22	1	KLHL22 [cytosol] (R-HSA-8863210)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.527	8
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.527	2
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.527	8
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.527	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	6
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	2
UniProt:P62899 RPL31	1	RPL31 [cytosol] (R-HSA-72454)	0.527	2
UniProt:Q02878 RPL6	1	RPL6 [cytosol] (R-HSA-72484)	0.527	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.527	8
UniProt:Q16778 H2BC21	9	Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) HIST2H2BE [extracellular region] (R-HSA-977571) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) HIST2H2BE [nucleoplasm] (R-HSA-181908)	0.527	2
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.527	3
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	7
UniProt:P62244 RPS15A	2	RPS15A [nucleoplasm] (R-HSA-6791191) RPS15A [cytosol] (R-HSA-72345)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	2
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.527	2
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.524	2
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.524	2
UniProt:Q9Y5A7-1 NUB1	1	NUB1-1 [cytosol] (R-HSA-8956129)	0.508	3
UniProt:P62081 RPS7	2	RPS7 [nucleoplasm] (R-HSA-6790635) RPS7 [cytosol] (R-HSA-72383)	0.499	2
UniProt:Q8WXE9 STON2	2	NEDD8-STON2 [cytosol] (R-HSA-8863733) STON2 [cytosol] (R-HSA-8862856)	0.499	2
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.499	2
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.499	2

Cite Us!