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NEDD8 [cytosol]
Stable Identifier
R-HSA-416969
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NEDD8_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P61086 UBE2K
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
NEDD8 [cytosol] (Homo sapiens)
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
NEDD8 [cytosol] (Homo sapiens)
Release of mature NEDD8 (Homo sapiens)
NEDD8 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)
NEDD8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15843 NEDD8
Gene Names
NEDD8
Chain
chain:1-76, propeptide:77-81
Reference Genes
BioGPS Gene:4738 NEDD8
COSMIC (genes):NEDD8 NEDD8
CTD Gene:4738 NEDD8
dbSNP Gene:4738 NEDD8
ENSEMBL:ENSG00000129559 NEDD8
ENSEMBL_homo_sapiens_GENE:ENSG00000129559.13 NEDD8
ENSEMBL_homo_sapiens_GENE:ENSG00000285246.2 NEDD8
HGNC:7732 NEDD8
KEGG Gene (Homo sapiens):4738 NEDD8
Monarch:4738 NEDD8
NCBI Gene:4738 NEDD8
OMIM:603171 NEDD8
UCSC:Q15843 NEDD8
Reference Transcript
RefSeq:NM_006156.2 NEDD8
Other Identifiers
11715967_a_at
11715968_s_at
11754081_a_at
11754082_x_at
11757472_x_at
1695_at
201840_PM_at
201840_at
2344451
2344453
3557987
3557988
3557989
3557990
3557993
3557995
3558005
4738
7978201
A_23_P88420
A_24_P301240
D23662_at
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006508
GO:0006511
GO:0008104
GO:0009653
GO:0019941
GO:0030162
GO:0030163
GO:0031386
GO:0031625
GO:0036211
GO:0043226
GO:0045116
GO:0048856
GO:0070062
HMNXSV003034944
ILMN_1785711
PH_hs_0004335
TC14001936.hg
TC14002343.hg
g5453759_3p_at
Participates
as an output of
Release of mature NEDD8 (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
as a component of
UCHL3,SENP8:NEDD8 [cytosol] (Homo sapiens)
NEDD8-UBA3:NAE1:NEDD8 [cytosol] (Homo sapiens)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Homo sapiens)
as an input of
NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)
NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Homo sapiens)
as a member of
NEDD8,UBD [cytosol] (Homo sapiens)
as a repeated unit of
monoNEDD8 [cytosol] (Homo sapiens)
Other forms of this molecule
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
NEDD8 [nucleoplasm]
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
NEDD8(77-81) [cytosol]
NEDD8(1-81) [cytosol]
C237-UBA3-G76-NEDD8 [cytosol]
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
Inferred To
RUB1 [cytosol]
(Saccharomyces cerevisiae)
ubl1 [cytosol]
(Schizosaccharomyces pombe)
nedd8 [cytosol]
(Dictyostelium discoideum)
nedd8 [cytosol]
(Xenopus tropicalis)
ned-8 [cytosol]
(Caenorhabditis elegans)
nedd8l [cytosol]
(Danio rerio)
NEDD8 [cytosol]
(Bos taurus)
NEDD8 [cytosol]
(Canis familiaris)
NEDD8 [cytosol]
(Gallus gallus)
NEDD8 [cytosol]
(Plasmodium falciparum)
NEDD8 [cytosol]
(Sus scrofa)
Nedd8 [cytosol]
(Drosophila melanogaster)
Nedd8 [cytosol]
(Mus musculus)
Nedd8 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_006147.1
OpenTargets
ENSG00000129559
GeneCards
Q15843
HPA
ENSG00000129559-NEDD8
Ensembl
ENSG00000129559
,
ENSG00000285246
,
ENSP00000250495
,
ENSP00000496420
,
ENST00000643069
,
ENST00000250495
PRO
Q15843
Pharos - Targets
Q15843
PDB
2BKR
,
2N7K
,
2KO3
,
3DQV
,
1XT9
,
3DBH
,
6R7I
,
4HCP
,
2NVU
,
8WQC
,
1R4M
,
8Q7H
,
3DBL
,
7ONI
,
8RX0
,
7B5L
,
8B3I
,
4FBJ
,
8CAF
,
3DBR
,
4F8C
,
3GZN
,
6TTU
,
1R4N
,
6R7F
,
8H38
,
7B5N
,
4P5O
,
1NDD
,
8WQG
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.961
23
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.936
11
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.802
7
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.725
9
UniProt:P62913 RPL11
1
RPL11 [cytosol]
(R-HSA-72406)
0.723
5
UniProt:O15037 KHNYN
0.698
13
UniProt:Q13564 NAE1
1
NAE1 [cytosol]
(R-HSA-8951449)
0.669
7
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.666
4
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.666
4
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.643
5
UniProt:P23396 RPS3
2
RPS3 [nucleoplasm]
(R-HSA-6798714)
RPS3 [cytosol]
(R-HSA-72369)
0.623
3
UniProt:P60866 RPS20
2
RPS20 [nucleoplasm]
(R-HSA-6798727)
RPS20 [cytosol]
(R-HSA-72349)
0.623
3
UniProt:Q13098 GPS1
2
GPS1 [nucleoplasm]
(R-HSA-5697010)
GPS1 [cytosol]
(R-HSA-416972)
0.592
6
UniProt:Q8TBC4 UBA3
2
UBA3 [cytosol]
(R-HSA-947632)
G76-NEDD8-C237-UBA3 [cytosol]
(R-HSA-8951640)
0.564
6
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P61086 UBE2K
2
UBE2K [cytosol]
(R-HSA-934631)
Ub-C92-UBE2K [cytosol]
(R-HSA-8864200)
0.556
3
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:P62266 RPS23
3
3OHP62-RPS23 [nucleoplasm]
(R-HSA-9630773)
RPS23 [nucleoplasm]
(R-HSA-6791209)
RPS23 [cytosol]
(R-HSA-72353)
0.527
2
UniProt:P62701 RPS4X
2
RPS4X [nucleoplasm]
(R-HSA-6798713)
RPS4X [cytosol]
(R-HSA-72375)
0.527
2
UniProt:Q05639 EEF1A2
1
EEF1A2 [cytosol]
(R-HSA-3907261)
0.527
2
UniProt:P62424 RPL7A
1
RPL7A [cytosol]
(R-HSA-72488)
0.527
2
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.527
2
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
2
UniProt:Q53GT1 KLHL22
1
KLHL22 [cytosol]
(R-HSA-8863210)
0.527
2
UniProt:P62241 RPS8
2
RPS8 [nucleoplasm]
(R-HSA-6791203)
RPS8 [cytosol]
(R-HSA-72385)
0.527
2
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.527
8
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.527
2
UniProt:Q13617 CUL2
3
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
CUL2 [nucleoplasm]
(R-HSA-1234126)
CUL2 [cytosol]
(R-HSA-416982)
0.527
8
UniProt:P46777 RPL5
1
RPL5 [cytosol]
(R-HSA-72482)
0.527
2
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.527
6
UniProt:Q9BQ90 KLHDC3
1
KLHDC3 [cytosol]
(R-HSA-535552)
0.527
2
UniProt:P62899 RPL31
1
RPL31 [cytosol]
(R-HSA-72454)
0.527
2
UniProt:Q02878 RPL6
1
RPL6 [cytosol]
(R-HSA-72484)
0.527
2
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.527
8
UniProt:Q16778 H2BC21
9
Ub-HIST2H2BE [nucleoplasm]
(R-HSA-6782539)
Ack-HIST2H2BE [nucleoplasm]
(R-HSA-4549257)
HIST2H2BE [extracellular region]
(R-HSA-977571)
AcK13-HIST2H2BE [nucleoplasm]
(R-HSA-4568651)
AcK21-HIST2H2BE [nucleoplasm]
(R-HSA-4568716)
AcK6-HIST2H2BE [nucleoplasm]
(R-HSA-4568679)
AcK16-HIST2H2BE [nucleoplasm]
(R-HSA-4568660)
Ub-121-HIST2H2BE [nucleoplasm]
(R-HSA-3364018)
HIST2H2BE [nucleoplasm]
(R-HSA-181908)
0.527
2
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.527
3
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.527
7
UniProt:P62244 RPS15A
2
RPS15A [nucleoplasm]
(R-HSA-6791191)
RPS15A [cytosol]
(R-HSA-72345)
0.527
2
UniProt:P62249 RPS16
2
RPS16 [nucleoplasm]
(R-HSA-6791196)
RPS16 [cytosol]
(R-HSA-72337)
0.527
2
UniProt:P62917 RPL8
3
3OHH216-RPL8 [nucleoplasm]
(R-HSA-9630976)
RPL8 [nucleoplasm]
(R-HSA-9630985)
RPL8 [cytosol]
(R-HSA-72490)
0.527
2
UniProt:Q9UNA4 POLI
1
POLI [nucleoplasm]
(R-HSA-5656133)
0.524
2
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.524
2
UniProt:Q9Y5A7-1 NUB1
1
NUB1-1 [cytosol]
(R-HSA-8956129)
0.508
3
UniProt:P62081 RPS7
2
RPS7 [nucleoplasm]
(R-HSA-6790635)
RPS7 [cytosol]
(R-HSA-72383)
0.499
2
UniProt:Q8WXE9 STON2
2
NEDD8-STON2 [cytosol]
(R-HSA-8863733)
STON2 [cytosol]
(R-HSA-8862856)
0.499
2
UniProt:P18124 RPL7
1
RPL7 [cytosol]
(R-HSA-72486)
0.499
2
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.499
2
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