Reactome | CUL2 [cytosol]

CUL2 [cytosol]

Stable Identifier

R-HSA-416982

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cullin-2, CUL2_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        CUL2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13617 CUL2

Gene Names

CUL2

Chain

chain:1-745

Reference Genes

BioGPS Gene:8453 CUL2

COSMIC (genes):CUL2 CUL2

CTD Gene:8453 CUL2

dbSNP Gene:8453 CUL2

ENSEMBL:ENSG00000108094 CUL2

ENSEMBL_homo_sapiens_GENE:ENSG00000108094.17 CUL2

HGNC:2552 CUL2

KEGG Gene (Homo sapiens):8453 CUL2

Monarch:8453 CUL2

NCBI Gene:8453 CUL2

OMIM:603135 CUL2

UCSC:Q13617 CUL2

Reference Transcript

Other Identifiers

11720418_a_at

11748246_a_at

16713264

203078_PM_at

203078_at

203079_PM_s_at

203079_s_at

3284883

3284884

3284885

3284886

3284887

3284888

3284891

3284894

3284895

3284897

3284901

3284902

3284903

3284904

3284905

3284906

3284907

3284908

3284909

3284910

3284911

3284912

3284913

3284914

3284917

3284918

3284920

3284921

3284922

3284923

3284924

37894_at

7933047

8453

A_24_P252794

GE59493

GO:0000082

GO:0000278

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0006511

GO:0012501

GO:0016567

GO:0016740

GO:0019005

GO:0023052

GO:0030163

GO:0030674

GO:0030891

GO:0031146

GO:0031461

GO:0031462

GO:0031625

GO:0036211

GO:0043226

GO:0044877

GO:0060090

GO:0097193

GO:0140096

GO:0140627

GO:0160072

Hs.82919.0.S3_3p_at

ILMN_1669252

PH_hs_0004743

TC10001173.hg

U83410_at

g4503162_3p_a_at

Participates

as a component of

Other forms of this molecule

G76-NEDD8-K689-CUL2 [cytosol]

CUL2 [nucleoplasm]

Inferred To

CUL2 [cytosol] (Bos taurus)

CUL2 [cytosol] (Canis familiaris)

CUL2 [cytosol] (Gallus gallus)

CUL2 [cytosol] (Sus scrofa)

culA [cytosol] (Dictyostelium discoideum)

Cul2 [cytosol] (Drosophila melanogaster)

Cul2 [cytosol] (Mus musculus)

Cul2 [cytosol] (Rattus norvegicus)

cul-2 [cytosol] (Caenorhabditis elegans)

Ghost homologue of CUL2 [cytosol] (Danio rerio)

culB [cytosol] (Dictyostelium discoideum)

Homologues of CUL2 [cytosol] (Dictyostelium discoideum)

culE [cytosol] (Dictyostelium discoideum)

cul2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003582.2, XP_011518049.1, NP_001185706.1, NP_001185708.1, NP_001185707.1

OpenTargets

ENSG00000108094

HPA

ENSG00000108094-CUL2

GeneCards

Q13617

Ensembl

ENSP00000363880, ENSP00000363881, ENSG00000108094, ENSP00000363883, ENSP00000414095, ENST00000421317, ENST00000374749, ENST00000374748, ENST00000690393, ENSP00000510691, ENST00000691974, ENST00000673636, ENSP00000501215, ENSP00000508908, ENST00000374751

PRO

Q13617

Pharos - Targets

Q13617

PDB

5N4W, 8PQL, 8JAR, 6R7N, 8JAS, 6R7H, 6R7I, 8JAQ, 8WQC, 6R6H, 8WQE, 8RWZ, 8WQA, 8JAU, 8WQB, 8JAV, 8RX0, 8R5H, 4WQO, 8WQH, 8JE1, 8Q7R, 8WQF, 8WQG, 6R7F, 8JAL, 8JE2, 8QU8, 8IJ1, 7PLO

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.916	19
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.85	9
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.802	10
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.708	11
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.708	20
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.643	3
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.643	8
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.641	3
UniProt:Q15048 LRRC14	1	LRRC14 [cytosol] (R-HSA-9749455)	0.623	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:Q04323 UBXN1	2	UBXN1 [cytosol] (R-HSA-8850588) UBXN1 [nucleoplasm] (R-HSA-9707052)	0.527	3
UniProt:P01185 AVP	10	AVP(20-28) [extracellular region] (R-HSA-388474) AVP(20-28) [cytosol] (R-HSA-879509) AVP E47del [extracellular region] (R-HSA-5621396) AVP P7L [extracellular region] (R-HSA-5621460) AVP C67* [extracellular region] (R-HSA-5621431) AVP V67A [extracellular region] (R-HSA-5621446) AVP A1T [extracellular region] (R-HSA-5621473) AVP Y2H [extracellular region] (R-HSA-5621449) AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	8
UniProt:A1L190 SYCE3	1	SYCE3 [nucleoplasm] (R-HSA-8867779)	0.527	3
UniProt:P01178 OXT	1	OXT(20-28) [extracellular region] (R-HSA-388430)	0.527	2