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SETDB1 [nucleoplasm]
Stable Identifier
R-HSA-417136
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase SETDB1, SETB1_HUMAN, ESET, KMT1E
Locations in the PathwayBrowser for interactor UniProt:P04183 TK1
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
ATF7IP binds SETDB1 (Homo sapiens)
SETDB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15047 SETDB1
Gene Names
SETDB1, ESET, KIAA0067, KMT1E
Chain
chain:1-1291
Reference Genes
COSMIC (genes):SETDB1 SETDB1
dbSNP Gene:9869 SETDB1
ENSEMBL:ENSG00000143379 SETDB1
Participates
as a component of
me3-K16-ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
as an input of
ATF7IP binds SETDB1 (Homo sapiens)
Inferred To
SETDB1 [nucleoplasm]
(Bos taurus)
SETDB1 [nucleoplasm]
(Canis familiaris)
SETDB1 [nucleoplasm]
(Danio rerio)
SETDB1 [nucleoplasm]
(Drosophila melanogaster)
SETDB1 [nucleoplasm]
(Gallus gallus)
SETDB1 [nucleoplasm]
(Mus musculus)
SETDB1 [nucleoplasm]
(Sus scrofa)
Setdb1 [nucleoplasm]
(Rattus norvegicus)
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.639
9
UniProt:Q9Y6K1 DNMT3A
2
DNMT3A [nucleoplasm]
(R-HSA-212287)
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
0.61
7
UniProt:Q9UIS9 MBD1
2
MBD1 [nucleoplasm]
(R-HSA-417134)
monoSUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
0.581
3
UniProt:Q99549 MPHOSPH8
1
MPHOSPH8 [nucleoplasm]
(R-HSA-9844052)
0.564
3
UniProt:Q9H9J2 MRPL44
1
MRPL44 [mitochondrial inner membrane]
(R-HSA-5368245)
0.553
2
UniProt:Q15714 T22D1
0.553
2
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.553
2
UniProt:P04183 TK1
1
TK1 [cytosol]
(R-HSA-73500)
0.553
2
UniProt:P11802 CDK4
3
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
CDK4 [nucleoplasm]
(R-HSA-113843)
CDK4 [cytosol]
(R-HSA-68330)
0.553
2
UniProt:P61956 SUMO2
6
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
(R-HSA-9761546)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
lysyl-G93-SUMO2 [cytosol]
(R-HSA-9834803)
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
0.553
2
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
0.553
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.527
2
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.524
3
UniProt:Q9NWR8 MCUB
1
MCUB [mitochondrial inner membrane]
(R-HSA-8949153)
0.499
3
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