Reactome | SMARCA5 [nucleoplasm]

SMARCA5 [nucleoplasm]

Stable Identifier

R-HSA-417140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, SNF2H, SMCA5_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P01106 MYC

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External Reference Information

External Reference

UniProt:O60264 SMARCA5

Gene Names

SMARCA5, SNF2H, WCRF135

Chain

initiator methionine:1, chain:2-1052

Reference Genes

BioGPS Gene:8467 SMARCA5

COSMIC (genes):SMARCA5 SMARCA5

CTD Gene:8467 SMARCA5

dbSNP Gene:8467 SMARCA5

ENSEMBL:ENSG00000153147 SMARCA5

HGNC:11101 SMARCA5

KEGG:hsa:8467 SMARCA5

Monarch:8467 SMARCA5

NCBI Gene:8467 SMARCA5

OMIM:603375 SMARCA5

UCSC:O60264 SMARCA5

Reference Transcript

RefSeq:NM_003601.3 SMARCA5

Other Identifiers

11718423_a_at

11764117_s_at

16971048

16971078

202303_PM_x_at

202303_x_at

213251_PM_at

213251_at

213859_PM_x_at

213859_x_at

240063_PM_at

240063_at

2745657

2745658

2745659

2745660

2745661

2745662

2745667

2745670

2745671

2745673

2745674

2745675

2745676

2745677

2745678

2745680

2745682

2745683

2745684

2745686

2745687

2745688

2745689

2745690

2745691

2745692

2745693

2745694

2745695

2745699

2745700

2745701

2745702

2745703

2745704

2745705

2745709

2745711

2745713

2745714

2745715

2745716

2745717

2745718

2745719

2745720

3053729

3709817

39132_at

75093_at

77754_at

8097600

8097626

8467

ADDON000038.hg

A_14_P201342

A_21_P0012750

A_23_P256716

A_23_P406591

A_32_P213678

GE578024

GE79039

GO:0000183

GO:0000785

GO:0000793

GO:0001650

GO:0003677

GO:0003682

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005677

GO:0005694

GO:0005721

GO:0005730

GO:0006275

GO:0006281

GO:0006325

GO:0006334

GO:0006338

GO:0006346

GO:0006352

GO:0006355

GO:0006357

GO:0006974

GO:0008623

GO:0016479

GO:0016589

GO:0016590

GO:0016787

GO:0016887

GO:0031010

GO:0031213

GO:0031491

GO:0031507

GO:0035861

GO:0042393

GO:0043596

GO:0045740

GO:0045893

GO:0045943

GO:0045944

GO:0045945

GO:0065003

GO:0090535

GO:0090536

GO:0090537

GO:0110016

GO:0140097

GO:0140374

GO:0140657

GO:0140658

GO:0140750

GO:0140751

GO:1905213

GO:1990830

HMNXSV003025925

HMNXSV003049298

Hs.130269.0.A1_3p_at

Hs.9456.1.A1_3p_a_at

Hs.9456.1.A1_3p_x_at

Hs.9456.2.A1_3p_at

ILMN_1693523

ILMN_1713163

ILMN_2223130

PH_hs_0022544

PH_hs_0036972

TC04000701.hg

TC04000702.hg

g4507074_3p_a_at

p34048

p34275

Participates

as a component of

as an input of

B-WICH complex binds rDNA promoter (Homo sapiens)

Inferred To

Smarca5 [nucleoplasm] (Mus musculus)

Smarca5 [nucleoplasm] (Rattus norvegicus)

smarca5 [nucleoplasm] (Danio rerio)

Iswi [nucleoplasm] (Drosophila melanogaster)

isw [nucleoplasm] (Dictyostelium discoideum)

SMARCA5 [nucleoplasm] (Bos taurus)

SMARCA5 [nucleoplasm] (Canis familiaris)

SMARCA5 [nucleoplasm] (Gallus gallus)

SMARCA5 [nucleoplasm] (Plasmodium falciparum)

SMARCA5 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003592.3

OpenTargets

ENSG00000153147

ENSEMBL

ENSP00000283131, ENSG00000153147, ENST00000283131

HPA

ENSG00000153147-SMARCA5

GeneCards

SMARCA5

PRO

O60264

Pharos - Targets

O60264

Orphanet

SMARCA5

GlyGen

O60264

PDB

9E1X, 9E1N, 9E1P, 9E1U, 9E1W, 9E1O, 9E1M, 8V7L, 8V4Y, 8V6V, 9E1R, 9E1L, 9E1Q, 6NE3, 9E1V

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.81	8
UniProt:Q9NRL2 BAZ1A			0.723	4
UniProt:Q96T23 RSF1	1	RSF1 [nucleoplasm] (R-HSA-606345)	0.675	6
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.643	3
UniProt:Q12830 BPTF			0.564	2
IntAct:EBI-22235520 SHDAG			0.558	3
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.544	2
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:P17096 HMGA1	2	HMGA1 [nucleoplasm] (R-HSA-3004623) HMGA1 [cytosol] (R-HSA-3004619)	0.527	2
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	2
UniProt:Q9NRF9 POLE3	1	POLE3 [nucleoplasm] (R-HSA-8866685)	0.527	3
UniProt:Q8IXM2 BAP18			0.527	2
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	5
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.527	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787)	0.462	2

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