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P2RY2 [plasma membrane]
Stable Identifier
R-HSA-417923
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2Y purinoceptor 2, P2RY2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
P2RY2 binds ATP (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Phosphorylation of PDPK1 on serine-241 (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Nucleotide-like (purinergic) receptors (Homo sapiens)
P2Y receptors (Homo sapiens)
P2Y2 receptor binds ATP and UTP (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41231 P2RY2
Gene Names
P2RY2, P2RU1
Chain
chain:1-377
Reference Genes
BioGPS Gene:5029 P2RY2
COSMIC (genes):P2RY2 P2RY2
CTD Gene:5029 P2RY2
dbSNP Gene:5029 P2RY2
ENSEMBL:ENSG00000175591 P2RY2
ENSEMBL_homo_sapiens_GENE:ENSG00000175591.12 P2RY2
HGNC:8541 P2RY2
KEGG Gene (Homo sapiens):5029 P2RY2
Monarch:5029 P2RY2
NCBI Gene:5029 P2RY2
OMIM:600041 P2RY2
UCSC:P41231 P2RY2
Reference Transcript
RefSeq:NM_176071.2 P2RY2
RefSeq:NM_176072.2 P2RY2
RefSeq:XM_005274021.4 P2RY2
RefSeq:XM_011545074.2 P2RY2
RefSeq:NM_002564.3 P2RY2
RefSeq:XM_005274019.4 P2RY2
RefSeq:XM_005274020.4 P2RY2
RefSeq:XM_017017839.1 P2RY2
Other Identifiers
11735662_a_at
16728778
206277_PM_at
206277_at
3339739
3339740
3339744
3339745
3339747
3339748
3339749
3339755
3339757
3339758
3339759
3339761
3339762
3339763
3339765
3339767
36292_at
5029
7942400
A_23_P24903
GO:0003013
GO:0004930
GO:0005515
GO:0005886
GO:0006873
GO:0007165
GO:0007186
GO:0007200
GO:0016020
GO:0023052
GO:0031686
GO:0035589
GO:0038023
GO:0045028
GO:0045030
GO:0060089
GO:0070257
GO:0071318
GO:0097746
HMNXSV003019859
ILMN_1690664
ILMN_1723535
ILMN_2297854
ILMN_2372915
PH_hs_0000043
TC11000772.hg
TC11002779.hg
U07225_at
g4505558_3p_at
Participates
as an input of
P2RY2 binds ATP (Homo sapiens)
P2Y2 receptor binds ATP and UTP (Homo sapiens)
as a component of
P2RY2:ATP [plasma membrane] (Homo sapiens)
P2RY2:ATP [plasma membrane] (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
Inferred To
P2ry2 [plasma membrane]
(Mus musculus)
P2ry2 [plasma membrane]
(Rattus norvegicus)
P2RY2 [plasma membrane]
(Bos taurus)
P2RY2 [plasma membrane]
(Canis familiaris)
P2RY2 [plasma membrane]
(Sus scrofa)
LOC116406441 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005274077.1
,
XP_005274078.1
,
NP_788086.2
,
NP_788085.2
,
XP_011543376.1
,
NP_002555.3
,
XP_016873328.1
,
XP_005274076.1
ZINC - World Drugs
P2RY2_HUMAN
Guide to Pharmacology - Targets
324
OpenTargets
ENSG00000175591
ZINC - Substances
P2RY2_HUMAN
ZINC - Biogenic
P2RY2_HUMAN
ZINC target
P41231
PRO
P41231
ZINC - Investigational
P2RY2_HUMAN
ZINC - Metabolites
P2RY2_HUMAN
GeneCards
P41231
HPA
ENSG00000175591-P2RY2
Ensembl
ENSP00000377222
,
ENSG00000175591
,
ENSP00000310305
,
ENST00000393597
,
ENSP00000377221
,
ENST00000311131
,
ENST00000393596
Pharos - Targets
P41231
ZINC - Predictions - Purchasable
P2RY2_HUMAN
HMDB Protein
HMDBP02449
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WUW1 BRK1
1
BRK1 [cytosol]
(R-HSA-1671645)
0.556
3
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