Reactome | P2RY6 [plasma membrane]

P2RY6 [plasma membrane]

Stable Identifier

R-HSA-417924

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

P2Y purinoceptor 6, P2RY6_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P60409

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External Reference Information

External Reference

UniProt:Q15077 P2RY6

Gene Names

P2RY6, PP2891

Chain

chain:1-328

Reference Genes

BioGPS Gene:5031 P2RY6

COSMIC (genes):P2RY6 P2RY6

CTD Gene:5031 P2RY6

dbSNP Gene:5031 P2RY6

ENSEMBL:ENSG00000171631 P2RY6

HGNC:8543 P2RY6

KEGG Gene (Homo sapiens):5031 P2RY6

Monarch:5031 P2RY6

NCBI Gene:5031 P2RY6

OMIM:602451 P2RY6

UCSC:Q15077 P2RY6

Reference Transcript

Other Identifiers

0000380411

0000610280

0001780364

11725227_at

11725228_a_at

16728788

208373_s_at

2406606

3339775

3339776

3339777

3339778

3339779

3339780

3339781

3339789

3339790

3339791

3339792

3339805

3339807

38222_at

5031

68778_at

7942409

A_14_P200317

A_23_P64611

GE54091

GO:0001621

GO:0003674

GO:0004930

GO:0005515

GO:0005575

GO:0005886

GO:0005887

GO:0005975

GO:0006464

GO:0006810

GO:0006909

GO:0007165

GO:0007186

GO:0007200

GO:0007202

GO:0008150

GO:0008283

GO:0009058

GO:0016020

GO:0016021

GO:0016192

GO:0031587

GO:0032962

GO:0035589

GO:0042592

GO:0044281

GO:0045028

GO:0045029

GO:0045030

GO:0055085

GO:0070374

GO:0071415

GO:1904707

GO:1905835

HMNXSV003033364

ILMN_1660031

ILMN_1782275

ILMN_1790029

PH_hs_0001515

TC11000773.hg

X97058_at

g4758863_3p_a_at

Participates

as an input of

P2Y6 receptor can bind to UDP (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

P2RY6:UDP [plasma membrane] (Homo sapiens)

Inferred To

P2RY3 [plasma membrane] (Gallus gallus)

P2RY6 [plasma membrane] (Bos taurus)

P2RY6 [plasma membrane] (Canis familiaris)

P2RY6 [plasma membrane] (Sus scrofa)

P2ry6 [plasma membrane] (Mus musculus)

P2ry6 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001264137.1, NP_001264133.1, NP_001264135.1, NP_789768.1, NP_001264134.1, XP_011543379.1, NP_789766.1, XP_011543381.1, NP_789767.1, XP_006718634.1, XP_005274079.1, NP_001264136.1

OpenTargets

ENSG00000171631

ZINC - Substances

P2RY6_HUMAN

ZINC target

Q15077

ZINC - Biogenic

P2RY6_HUMAN

PRO

Q15077

PDB

2B6R

ZINC - Investigational

P2RY6_HUMAN

ZINC - Metabolites

P2RY6_HUMAN

GeneCards

Q15077

HPA

ENSG00000171631-P2RY6

Ensembl

ENSP00000445652, ENSP00000442990, ENSG00000171631, ENSP00000442551, ENSP00000480966, ENST00000618468, ENSP00000309771, ENSP00000377217, ENST00000540124, ENST00000540342, ENST00000393591, ENST00000393592, ENSP00000377216, ENST00000349767, ENSP00000377215, ENST00000538328, ENST00000393590, ENSP00000443427, ENST00000542092

ZINC - Predictions - Purchasable

P2RY6_HUMAN

HMDB Protein

HMDBP07861

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-10171679 386682			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P0DPK4 NT2NC			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:O15162 PLS1			0.556	3
UniProt:Q8NI22 MCFD2	3	MCFD2 [endoplasmic reticulum membrane] (R-HSA-5689470) MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689836) MCFD2 [ER to Golgi transport vesicle membrane] (R-HSA-1017216)	0.556	3
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	5
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	5
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P55060 XPO2			0.499	2
UniProt:Q14974 KPNB1	5	KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.499	4

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