Reactome | P2Y2 receptor binds ATP and UTP

P2Y2 receptor binds ATP and UTP

Stable Identifier

R-HSA-417927

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y2 receptor binds ATP and UTP (Homo sapiens)

General

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The P2Y2 receptor (Parr CE et al, 1994) is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. The effects of P2Y2 are mediated by coupling with the G protein alpha Gq/11 subunits (Schachter JB et al, 1997). P2Y2 is a potential drug target for treating cystic fibrosis (Kellerman D et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
9364473	HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors Nicholas, RA, Harden, TK, Sromek, SM, Schachter, JB	Neuropharmacology	1997
12458155	Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease Kellerman, D, Shaffer, C, Mathews, D, Evans, R	Adv Drug Deliv Rev	2002
8159738	Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy Turner, JT, Erb, L, Olsen, JC, Burch, LH, Lazarowski, ER, Parr, CE, Weisman, GA, Paradiso, AM, Boucher, RC, Sullivan, DM	Proc Natl Acad Sci U S A	1994