Reactome | DAPK1 [cytosol]

DAPK1 [cytosol]

Stable Identifier

R-HSA-418262

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Death-associated protein kinase 1, DAPK1_HUMAN

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
      - DAPK binds UNC5B (Homo sapiens)
        
        DAPKs [cytosol] (Homo sapiens)
        
        DAPK1 [cytosol] (Homo sapiens)
        
        Unc5B with death domain:DAPK [cytosol] (Homo sapiens)
        
        DAPKs [cytosol] (Homo sapiens)
        
        DAPK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53355 DAPK1

Gene Names

DAPK1, DAPK

Chain

chain:1-1430

Reference Genes

BioGPS Gene:1612 DAPK1

COSMIC (genes):DAPK1 DAPK1

CTD Gene:1612 DAPK1

dbSNP Gene:1612 DAPK1

ENSEMBL:ENSG00000196730 DAPK1

ENSEMBL_homo_sapiens_GENE:ENSG00000196730.13 DAPK1

HGNC:2674 DAPK1

KEGG Gene (Homo sapiens):1612 DAPK1

Monarch:1612 DAPK1

NCBI Gene:1612 DAPK1

OMIM:600831 DAPK1

UCSC:P53355 DAPK1

Reference Transcript

Other Identifiers

11720146_a_at

11720147_a_at

11746545_a_at

1612

17086496

203139_PM_at

203139_at

211214_PM_s_at

211214_s_at

3177901

3177902

3177903

3177904

3177905

3177906

3177907

3177918

3177924

3177925

3177926

3177927

3177928

3177929

3177930

3177932

3177933

3177934

3177936

3177938

3177940

3177942

3177945

3177949

3177952

3177954

3177955

3177956

3177958

3177959

3177960

3177961

3177962

3177963

40049_at

8156199

A_14_P118103

A_23_P252163

A_24_P393449

A_33_P3737504

GE484162

GE60012

GO:0000166

GO:0002357

GO:0002376

GO:0002834

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005525

GO:0005634

GO:0005737

GO:0005856

GO:0005886

GO:0006417

GO:0006468

GO:0006796

GO:0006807

GO:0006914

GO:0006915

GO:0007165

GO:0008625

GO:0010468

GO:0010506

GO:0010508

GO:0012501

GO:0014069

GO:0015629

GO:0016301

GO:0016310

GO:0016740

GO:0017075

GO:0017148

GO:0023052

GO:0035556

GO:0036211

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043170

GO:0043226

GO:0043280

GO:0044238

GO:0045087

GO:0046777

GO:0048583

GO:0055085

GO:0071345

GO:0071346

GO:0071447

GO:0097190

GO:0098542

GO:0098978

GO:0106310

GO:0140096

GO:1904094

GO:1990722

GO:2000310

HMNXSV003005055

HMNXSV003052740

ILMN_1708340

PH_hs_0023201

TC09000398.hg

X76104_at

g13177655_3p_a_at

g4826683_3p_at

Participates

as a member of

DAPKs [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001275658.1, NP_004929.2, NP_001275660.1, NP_001275659.1

ZINC - World Drugs

DAPK1_HUMAN

Guide to Pharmacology - Targets

2002

OpenTargets

ENSG00000196730

ZINC - FDA approved

DAPK1_HUMAN

ZINC - Substances

DAPK1_HUMAN

ZINC - Biogenic

DAPK1_HUMAN

ZINC target

P53355

PRO

P53355

PDB

6FHB, 5AUU, 4YPD, 8IE6, 5AUV, 1IG1, 3DGK, 5AV4, 3GU7, 3DFC, 3EH9, 4B4L, 3GU8, 5AUZ, 2XZS, 1JKL, 4TL0, 4PF4, 1JKK, 6AAR, 5AV3, 1WVW, 8IE7, 3GU5, 2X0G, 5AUW, 5AUX, 4YO4, 2W4K, 2YAK, 2W4J, 5AUY, 6FHA, 2XUU, 7CCW, 6QMO, 2Y0A, 3GU6, 8IE5, 6QN4, 3GUB, 6GY5, 4TXC, 7CCU, 2Y4P, 6IN4, 1YR5, 7CCV, 5AUT, 5AV1, 1P4F, 4UV0, 1WVX, 2Y4V, 5AV2, 3EHA, 3F5G, 1JKT, 3GU4, 3ZXT, 1JKS, 3F5U, 1WVY, 8IE8, 5AV0

ZINC - Investigational

DAPK1_HUMAN

HPA

ENSG00000196730-DAPK1

GeneCards

P53355

Ensembl

ENST00000358077, ENST00000469640, ENST00000408954, ENST00000491893, ENST00000472284, ENST00000622514, ENSG00000196730, ENSP00000419026, ENSP00000418885, ENSP00000417076, ENSP00000350785, ENSP00000484267, ENSP00000386135

Pharos - Targets

P53355

ZINC - Predictions - Purchasable

DAPK1_HUMAN

HMDB Protein

HMDBP01259

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13284 IFI30	1	IFI30 [lysosomal lumen] (R-HSA-1031704)	0.643	3
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.618	5
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.591	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.59	2
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.527	3
UniProt:P14618-1 PKM	2	PolyUb-PKM-1 [cytosol] (R-HSA-9861692) PKM-1 [cytosol] (R-HSA-71667)	0.527	2