There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

ATP2B1-4 transport cytosolic Ca2+ to extracellular region

Stable Identifier
R-HSA-418309
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
PMCA extrusion of Ca2+
Locations in the PathwayBrowser
Summation

The plasma membrane Ca-ATPases 1-4 (ATP2B1-4, PMCAs) are P-type Ca2+-ATPases regulated by calmodulin. The PMCA also counter-transports a proton. PMCA is important for Ca2+ homeostasis and function.

Literature References
PubMed ID Title Journal Year
2844759 Complete primary structure of a human plasma membrane Ca2+ pump J Biol Chem 1988
5961668 ATP-dependent Ca++-extrusion from human red cells Experientia 1966
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium-transporting ATPase activity of ATP2B1-4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea