Reactome: A Curated Pathway Database

cAMP degradation by Phosphodiesterases

Stable Identifier
R-HSA-418553
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
3',5'-cyclic-AMP phosphodiesterase activity of cAMP phosphodiesterases [cytosol] cAMP phosphodiesterases [cytosol] 3',5'-cyclic-AMP phosphodiesterase activity (0004115)
Orthologous Events