cAMP degradation by Phosphodiesterases

Stable Identifier
R-HSA-418553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.

Literature References
PubMed ID Title Journal Year
  The Cell - A Molecular Approach

Cooper, GM, Hausman, RE

  2002
15769620 Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system

Maurice, DH

Front Biosci 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3',5'-cyclic-AMP phosphodiesterase activity of cAMP phosphodiesterases [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created