G alpha (i) signalling events

Stable Identifier
R-HSA-418594
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase (Dessauer C W et al. 2002). Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. Other functions of G alpha (i) includes activation of the protein tyrosine kinase c-Src (Ma Y C et al. 2000). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (i) (Soundararajan M et al. 2008).

Literature References
PubMed ID Title Journal Year
9278091 Role of subunit diversity in signaling by heterotrimeric G proteins Biochem Pharmacol 1997
3113327 G proteins: transducers of receptor-generated signals Annu Rev Biochem 1987
Participants
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Orthologous Events