G alpha (z) signalling events

Stable Identifier
R-HSA-418597
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The heterotrimeric G protein G alpha (z), is a member of the G (i) family. Unlike other G alpha (i) family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis toxin-insensitive. It inhibits adenylyl cyclase types I, V and VI (Wong Y H et al. 1992). G alpha (z) interacts with the Rap1 GTPase activating protein (Rap1GAP) to attenuate Rap1 signaling. Like all G-proteins G alpha (z) has an intrinsic GTPase activity, but this activity tends to be lower for the pertussis toxin insensitive G-proteins, most strikingly so for G alpha (z), whose kcat value for GTP hydrolysis is 200-fold lower than those of G alpha (s) or G alpha (i) (Grazziano et al. 1989). G alpha (z) knockout mice have disrupted platelet aggregation at physiological concentrations of epinephrine and responses to several neuroactive drugs are altered (Yang et al. 2000). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (z) (Soundararajan M et al. 2008).

Literature References
PubMed ID Title Journal Year
11313909 G(z) signaling: emerging divergence from G(i) signaling

Ho, MK, Wong, YH

Oncogene 2001
1908722 Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes

Gagnon, AW, Manning, DR, Catani, L, Gewirtz, A, Poncz, M, Brass, LF

Blood 1991
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed
Created