G alpha (z) signalling events

Stable Identifier
R-HSA-418597
Type
Pathway
Species
Homo sapiens
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The heterotrimeric G protein G alpha (z), is a member of the G (i) family. Unlike other G alpha (i) family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis toxin-insensitive. It inhibits adenylyl cyclase types I, V and VI (Wong Y H et al. 1992). G alpha (z) interacts with the Rap1 GTPase activating protein (Rap1GAP) to attenuate Rap1 signaling. Like all G-proteins G alpha (z) has an intrinsic GTPase activity, but this activity tends to be lower for the pertussis toxin insensitive G-proteins, most strikingly so for G alpha (z), whose kcat value for GTP hydrolysis is 200-fold lower than those of G alpha (s) or G alpha (i) (Grazziano et al. 1989). G alpha (z) knockout mice have disrupted platelet aggregation at physiological concentrations of epinephrine and responses to several neuroactive drugs are altered (Yang et al. 2000). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (z) (Soundararajan M et al. 2008).

Literature References
PubMed ID Title Journal Year
11313909 G(z) signaling: emerging divergence from G(i) signaling

Ho, MK, Wong, YH

Oncogene 2001
1908722 Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes

Gagnon, AW, Manning, DR, Catani, L, Gewirtz, A, Poncz, M, Brass, LF

Blood 1991
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Orthologous Events
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