Src activation following P2Y purinoceptor activation

Stable Identifier
R-HSA-418662
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activation of Src lies selectively downstream of P2Y1, but not P2Y12. The precise mechanism is not known, but Src regulation of the PI3K component of the intracellular calcium response downstream of P2Y12 represents a point of reciprocal cross-talk between P2Y1 and P2Y12 receptors.

Literature References
PubMed ID Title Journal Year
15187029 Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets

Hardy, AR, Jones, ML, Mundell, SJ, Poole, AW

Blood 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created