Recruitment of ABLIM to the plasma membrane

Stable Identifier
R-HSA-418865
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of ABLIM to the plasma membrane
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Unc-115/AbLIM is a key regulator of lamellipodia and filopodia in the growth cone during axon pathfinding and acts downstream of Rac GTPase signaling. It acts as a scaffold to recruit other actin-modulating complexes involved in lamellipodia and filopodia. Unc-115/AbLIM is locally recruited to the plasma membrane by activated Rac1 and subsequently dephosphorylated on serine 617. Dephosphorylated Unc-115/AbLIM then might interact with other molecules at the plasma membrane to induce formation of lamellipodia and filopodia by reorganization of the actin cytoskeleton.
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Inferred From
Recruitment of ABLIM to the plasma membrane (Caenorhabditis elegans)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
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