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PITPalpha binds DCC
Stable Identifier
R-HSA-418866
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
Role of second messengers in netrin-1 signaling (Homo sapiens)
PITPalpha binds DCC (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DCC interacts directly with PITPalpha and this interaction is enhanced in the presence of Netrin-1. The interaction of DCC with PITPalpha requires the carboxy-terminal dmain of both the proteins. PITPalpha signaling pathway is important for netrin-1 mediated axon outgrowth. Netrin-1 activates PITPalpha to regulate local phosphoinositide (PI) synthesis, which is important for PI3K dependent neurite elongation.
Participants
Input
NTN1:DCC oligomer [plasma membrane]
(Homo sapiens)
PITPNA [cytosol]
(Homo sapiens)
Output
NTN1:DCC:PITPNA [plasma membrane]
(Homo sapiens)
Participates
as an event of
Role of second messengers in netrin-1 signaling (Homo sapiens)
Inferred From
PITPalpha binds DCC (Mus musculus)
Authored
Garapati, P V (2009-04-27)
Reviewed
Cooper, HM (2010-02-16)
Created
Garapati, P V (2009-04-27)
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