Recruitment of Src and Fyn to DCC:FADK1

Stable Identifier
R-HSA-418868
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated (phosphorylated) FADK1 acts as a scaffold and recruits src tyrosine kinases Src and Fyn to DCC. These tyrosine kinases phosphorylate DCC which is critical for Netrin-1 signaling.

Literature References
PubMed ID Title Journal Year
15494734 Activation of FAK and Src are receptor-proximal events required for netrin signaling

Li, W, Lee, J, Vikis, HG, Lee, SH, Liu, G, Aurandt, J, Shen, TL, Fearon, ER, Guan, JL, Han, M, Rao, Y, Hong, K, Guan, KL

Nat Neurosci 2004
15557120 Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance

Meriane, M, Tcherkezian, J, Webber, CA, Danek, EI, Triki, I, McFarlane, S, Bloch-Gallego, E, Lamarche-Vane, N

J Cell Biol 2004
15494732 Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction

Liu, G, Beggs, H, Jürgensen, C, Park, HT, Tang, H, Gorski, J, Jones, KR, Reichardt, LF, Wu, J, Rao, Y

Nat Neurosci 2004
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