Phosphorylation of FADK1

Stable Identifier
R-HSA-418872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of FADK1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FADK1 interacts with the C-terminal P3 domain of DCC complexed with Netrin-1, and undergoes tyrosine phosphorylation and activation. Netrin-1-DCC binding thus leads to the autophosphorylation of tyrosine 393 in FADK1.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of NTN1:DCC oligomer:PTK2 [plasma membrane]

Physical Entity
NTN1:DCC oligomer:PTK2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of FADK1 (Mus musculus)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2009-04-27)
Cite Us!