Reactome | ADORA2B [plasma membrane]

ADORA2B [plasma membrane]

Stable Identifier

R-HSA-418898

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenosine receptor A2b, AA2BR_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        ADORA2B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
        
        Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Homo sapiens)
        
        ADORA2B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADORA2A,B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADORA2A,B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADORA2A,B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADORA2A,B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        ADORA2A,B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        Adenosine P1 receptors (Homo sapiens)
        
        ADORA2A,B bind Ade-Rib (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)
        
        ADORA2A,B:Ade-Rib [plasma membrane] (Homo sapiens)
        
        ADORA2A,B [plasma membrane] (Homo sapiens)
        
        ADORA2B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29275 ADORA2B

Gene Names

ADORA2B

Chain

chain:1-332

Reference Genes

BioGPS Gene:136 ADORA2B

COSMIC (genes):ADORA2B ADORA2B

CTD Gene:136 ADORA2B

dbSNP Gene:136 ADORA2B

ENSEMBL:ENSG00000170425 ADORA2B

HGNC:264 ADORA2B

KEGG:hsa:136 ADORA2B

Monarch:136 ADORA2B

NCBI Gene:136 ADORA2B

OMIM:600446 ADORA2B

UCSC:P29275 ADORA2B

Reference Transcript

RefSeq:NM_000676.2 ADORA2B

Other Identifiers

11741056_a_at

136

16831383

205891_PM_at

205891_at

36324_at

3711870

3711871

3711885

3711886

3711887

3711888

3711889

3711890

3711891

3711892

8005134

A_23_P55477

GE59945

GO:0001609

GO:0001973

GO:0002376

GO:0002882

GO:0003012

GO:0003013

GO:0004930

GO:0005515

GO:0005886

GO:0007186

GO:0007189

GO:0007190

GO:0010575

GO:0010753

GO:0016020

GO:0016192

GO:0019934

GO:0032722

GO:0032755

GO:0042311

GO:0043303

GO:0043306

GO:0045202

GO:0060087

GO:0060089

GO:0098685

GO:0098793

GO:0098978

GO:0099171

HMNXSV003026780

ILMN_1703946

PH_hs_0028884

TC17000180.hg

X68487_at

g4501950_3p_at

Participates

as an input of

ADORA2B binds Ade-Rib (Homo sapiens)

as an output of

ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)

as a component of

ADORA2B:Ade-Rib [plasma membrane] (Homo sapiens)

as a member of

ADORA2A,B [plasma membrane] (Homo sapiens)

Inferred To

adora2b [plasma membrane] (Danio rerio)

adora2b [plasma membrane] (Xenopus tropicalis)

Homologues of ADORA2B [plasma membrane] (Caenorhabditis elegans)

gtr-1 [plasma membrane] (Caenorhabditis elegans)

ADORA2B [plasma membrane] (Bos taurus)

ADORA2B [plasma membrane] (Caenorhabditis elegans)

ADORA2B [plasma membrane] (Gallus gallus)

ADORA2B [plasma membrane] (Mus musculus)

ADORA2B [plasma membrane] (Rattus norvegicus)

ADORA2B [plasma membrane] (Sus scrofa)

AdoR [plasma membrane] (Drosophila melanogaster)

ador-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000667.1

ZINC - World Drugs

AA2BR_HUMAN

Guide to Pharmacology - Targets

ENSEMBL

ENSP00000304501, ENST00000304222

OpenTargets

ENSG00000170425

ZINC - FDA approved

AA2BR_HUMAN

ZINC - Substances

AA2BR_HUMAN

ZINC - Biogenic

AA2BR_HUMAN

ZINC target

P29275

PRO

P29275

GlyGen

P29275

PDB

7XY7, 8HDP, 7XY6, 8HDO

ZINC - Investigational

AA2BR_HUMAN

ZINC - Metabolites

AA2BR_HUMAN

HPA

ENSG00000170425-ADORA2B

Pharos - Targets

P29275

ZINC - Predictions - Purchasable

AA2BR_HUMAN

HMDB Protein

HMDBP01656

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29274 ADORA2A	2	ADORA2A [plasma membrane] (R-HSA-418934) ADORA2A [Golgi membrane] (R-HSA-187668)	0.535	5