ADORA2A,B bind Ade-Rib

Stable Identifier
R-HSA-418925
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
A2a and A2b receptors bind adenosine
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Adenosine receptors A2a and A2b (ADORA2A and ADORA2B) bind extracellular adenosine (Ado-Rib) and are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow (Peterfreund 1996). The A2A receptor is responsible for regulating myocardial blood flow by vasodilation of the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. Just as in A1 receptors, this normally serves as a protective mechanism. A2B receptor work (Pierce KD et al, 1992) has lagged behind research in the other adenosine receptors.
Both ADORA receptors mediate their actions by coupling with the G protein alpha s subunit which activates adenylyl cyclase and increases intracellular cAMP concentrations. In surfactant physiology, the receptor:adenosine complex positively regulates surfactant export from lamellar bodies. (Cooper JA et al, 1995; Linden J et al, 1999). Adenosine deaminase (CECR1, ADA2) degrades extracellular adenosine (Ade-Rib), reducing or neutralising the positive regulatory effect of adenosine in surfactant export.

Literature References
PubMed ID Title Journal Year
8527267 Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets

Cooper, JA, Hill, SJ, Alexander, SP, Rubin, PC, Horn, EH

Br J Clin Pharmacol 1995
10496952 Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells

Linden, J, Thai, T, Figler, H, Jin, X, Robeva, AS

Mol Pharmacol 1999
1325798 Molecular cloning and expression of an adenosine A2b receptor from human brain

Pierce, KD, Furlong, TJ, Selbie, LA, Shine, J

Biochem Biophys Res Commun 1992
8522976 Characterization and expression of the human A2a adenosine receptor gene

Peterfreund, RA, MacCollin, M, Gusella, J, Fink, JS

J Neurochem 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created