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CDH4 [plasma membrane]
Stable Identifier
R-HSA-418991
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
R-cadherin, Cadherin-4, CADH4_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)
Cadherin trans-homodimer [cell junction] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)
Cadherin:Catenin complex [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Classic Cadherin [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Activation of p38 alpha/beta MAPK (Homo sapiens)
p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Bnip2 interacts with CDO complex (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
CDO binds promyogenic cadherins (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Interaction of ABL1 with CDO complex (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Interaction of Bnip-2 with Cdc42 (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Interaction of p38 MAPK with JLP (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
JLP interacts with CDO complex (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
Nuclear translocation of p38 MAPK (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
Trans-cadherin homodimers [plasma membrane] (Homo sapiens)
Cadherin:Catenin [plasma membrane] (Homo sapiens)
Promyogenic cadherins [plasma membrane] (Homo sapiens)
CDH4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55283 CDH4
Gene Names
CDH4
Chain
signal peptide:1-20, propeptide:21-169, chain:170-916
Reference Genes
BioGPS Gene:1002 CDH4
COSMIC (genes):CDH4 CDH4
CTD Gene:1002 CDH4
dbSNP Gene:1002 CDH4
ENSEMBL:ENSG00000179242 CDH4
ENSEMBL_homo_sapiens_GENE:ENSG00000179242.16 CDH4
HGNC:1763 CDH4
KEGG Gene (Homo sapiens):1002 CDH4
Monarch:1002 CDH4
NCBI Gene:1002 CDH4
OMIM:603006 CDH4
UCSC:P55283 CDH4
Reference Transcript
RefSeq:NM_001252339.2 CDH4
RefSeq:NM_001794.4 CDH4
Other Identifiers
1002
11755815_a_at
1483_at
16915541
206866_PM_at
206866_at
220227_PM_at
220227_at
3892090
3892091
3892093
3892133
3892172
3892173
3892174
3892184
3892185
3892202
3892207
3892221
3892234
3892249
3892259
3892260
3892261
3892266
3892269
3892275
3892276
3892278
3892279
3892326
3892328
3892330
3892331
3892332
3892334
63500_r_at
8063796
A_14_P115196
A_14_P132342
A_23_P17593
A_23_P28999
GE57729
GE85466
GO:0000902
GO:0005509
GO:0005886
GO:0005912
GO:0007043
GO:0007155
GO:0007156
GO:0007157
GO:0007411
GO:0016020
GO:0016339
GO:0016342
GO:0030154
GO:0034330
GO:0034332
GO:0044331
GO:0045296
GO:0045773
GO:0046872
GO:0048675
GO:0048856
GO:0098609
HMNXSV003024013
ILMN_1769891
L34059_at
PH_hs_0012392
PH_hs_0024269
PH_hs_0035867
PH_hs_0038050
TC20000481.hg
TC20001333.hg
g13376328_3p_at
g4502724_3p_at
Participates
as a candidate of
Promyogenic cadherins [plasma membrane] (Homo sapiens)
as a member of
Classic Cadherin [plasma membrane] (Homo sapiens)
Inferred To
CDH4 [plasma membrane]
(Bos taurus)
CDH4 [plasma membrane]
(Canis familiaris)
CDH4 [plasma membrane]
(Gallus gallus)
CDH4 [plasma membrane]
(Sus scrofa)
cdh4 [plasma membrane]
(Danio rerio)
cdh4 [plasma membrane]
(Xenopus tropicalis)
CadN2 [plasma membrane]
(Drosophila melanogaster)
Cdh4 [plasma membrane]
(Mus musculus)
Cross References
RefSeq
NP_001785.2
,
NP_001239268.1
OpenTargets
ENSG00000179242
GeneCards
P55283
HPA
ENSG00000179242-CDH4
Ensembl
ENST00000543233
,
ENSP00000484928
,
ENSP00000443301
,
ENSG00000179242
,
ENST00000614565
PRO
P55283
Pharos - Targets
P55283
HMDB Protein
HMDBP07520
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