Reactome | PVRL2 [plasma membrane]

PVRL2 [plasma membrane]

Stable Identifier

R-HSA-419006

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Nectin-2

Locations in the PathwayBrowser for interactor UniProt:P55196 AFDN

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External Reference Information

External Reference

UniProt:Q92692 NECTIN2

Gene Names

NECTIN2, HVEB, PRR2, PVRL2

Chain

signal peptide:1-31, chain:32-538

Reference Genes

BioGPS Gene:5819 NECTIN2

COSMIC (genes):NECTIN2 NECTIN2

CTD Gene:5819 NECTIN2

dbSNP Gene:5819 NECTIN2

ENSEMBL:ENSG00000130202 NECTIN2

HGNC:9707 NECTIN2

KEGG:hsa:5819 NECTIN2

Monarch:5819 NECTIN2

NCBI Gene:5819 NECTIN2

OMIM:600798 NECTIN2

UCSC:Q92692 NECTIN2

Reference Transcript

Participates

as a component of

as an input of

as a member of

Nectin [plasma membrane] (Homo sapiens)

Inferred To

Nectin2 [plasma membrane] (Mus musculus)

Nectin2 [plasma membrane] (Rattus norvegicus)

NECTIN2 [plasma membrane] (Bos taurus)

NECTIN2 [plasma membrane] (Canis familiaris)

NECTIN2 [plasma membrane] (Sus scrofa)

nectin2 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002847.1, NP_001036189.1

OpenTargets

ENSG00000130202

ENSEMBL

ENST00000252485, ENSP00000252485, ENSP00000252483, ENST00000252483, ENSG00000130202

HPA

ENSG00000130202-NECTIN2

GeneCards

NECTIN2

PRO

Q92692

Pharos - Targets

Q92692

GlyGen

Q92692

PDB

4HZA, 4DFI, 4DFH, 5V52, 3R0N, 8X6B

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92692 NECTIN2	1	PVRL2 [plasma membrane] (R-HSA-419006)	0.89	8
UniProt:Q495A1 TIGIT			0.786	6
UniProt:Q9NQS3 NECTIN3	1	PVRL3 [plasma membrane] (R-HSA-449762)	0.702	4
UniProt:Q99750 MDFI			0.666	4
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
IntAct:EBI-10173330 386677			0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P55196 AFDN			0.499	2
UniProt:Q9H3Z4 DNAJC5	5	DNAJC5 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888598) DNAJC5 [plasma membrane] (R-HSA-936512) DNAJC5 [specific granule membrane] (R-HSA-6800990) DNAJC5 [azurophil granule membrane] (R-HSA-6799144) DNAJC5 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659623)	0.471	2

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