ROCK activation by RHO

Stable Identifier
R-HSA-419049
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ROCKs are primarily known as downstream effectors of RHO, but they can also be activated by arachidonic acid, which binds to the pleckstrin homology domain, releasing an autoinhibitory loop within ROCK and allowing catalytic activity (Araki et al. 2001). Proteolytic cleavage at the C-terminus by caspase-3 and granzyme B also activates ROCK1 and ROCK2, causing plasma membrane blebbing during apoptosis (Coleman et al. 2001, Sebbagh et al. 2005). Multiple targets of ROCK contribute to the stabilization of actin filaments and the generation of actin-myosin contractile force.

Literature References
PubMed ID Title Journal Year
8816443 The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

Leung, T, Chen, XQ, Manser, E, Lim, L

Mol. Cell. Biol. 1996
11294240 Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase

Araki, S, Ito, M, Kureishi, Y, Feng, J, Machida, H, Isaka, N, Amano, M, Kaibuchi, K, Hartshorne, DJ, Nakano, T

Pflugers Arch. 2001
8617235 The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

Ishizaki, T, Maekawa, M, Fujisawa, K, Okawa, K, Iwamatsu, A, Fujita, A, Watanabe, N, Saito, Y, Kakizuka, A, Morii, N, Narumiya, S

EMBO J 1996
11283606 Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

Coleman, ML, Sahai, EA, Yeo, M, Bosch, M, Dewar, A, Olson, MF

Nat. Cell Biol. 2001
15699075 Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner

Sebbagh, M, Hamelin, J, Bertoglio, J, Solary, E, Breard, J

J. Exp. Med. 2005
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