Reactome | ROCK activation by RHO

ROCK activation by RHO

Stable Identifier

R-HSA-419049

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        ROCK activation by RHO (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (12/13) signalling events (Homo sapiens)
      - ROCK activation by RHO (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate ROCKs (Homo sapiens)
        
        ROCK activation by RHO (Homo sapiens)

General

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ROCKs are primarily known as downstream effectors of RHO, but they can also be activated by arachidonic acid, which binds to the pleckstrin homology domain, releasing an autoinhibitory loop within ROCK and allowing catalytic activity (Araki et al. 2001). Proteolytic cleavage at the C-terminus by caspase-3 and granzyme B also activates ROCK1 and ROCK2, causing plasma membrane blebbing during apoptosis (Coleman et al. 2001, Sebbagh et al. 2005). Multiple targets of ROCK contribute to the stabilization of actin filaments and the generation of actin-myosin contractile force.

Literature References

PubMed ID	Title	Journal	Year
11294240	Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase Isaka, N, Hartshorne, DJ, Kaibuchi, K, Kureishi, Y, Ito, M, Feng, J, Nakano, T, Machida, H, Amano, M, Araki, S	Pflugers Arch.	2001
8816443	The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton Lim, L, Manser, E, Leung, T, Chen, XQ	Mol. Cell. Biol.	1996
8617235	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase Saito, Y, Fujita, A, Narumiya, S, Okawa, K, Iwamatsu, A, Morii, N, Fujisawa, K, Kakizuka, A, Ishizaki, T, Watanabe, N, Maekawa, M	EMBO J	1996
11283606	Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I Olson, MF, Coleman, ML, Yeo, M, Dewar, A, Sahai, EA, Bosch, M	Nat. Cell Biol.	2001
15699075	Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner Bertoglio, J, Breard, J, Hamelin, J, Solary, E, Sebbagh, M	J. Exp. Med.	2005