Reactome: A Curated Pathway Database

LIM kinase phosphorylation by ROCK

Stable Identifier
R-HSA-419087
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. ROCK1 and ROCK2 phosphorylate and activate LIM kinases LIMK1 and LIMK2 at Thr508 and Thr505, respectively (Ohashi et al. 2000, Sumi et al. 2001). These threonine residues lay within the activation loop of the kinase domain. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, resulting in stabilization of the actin cytoskeleton (Pandey et al. 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of Activated ROCK:RhoA/B/C:GTP [plasma membrane] Activated ROCK:RhoA/B/C:GTP [plasma membrane] protein serine/threonine kinase activity (0004674)
Inferred From