Reactome: A Curated Pathway Database

GEFs activate RhoA,B,C

Stable Identifier
R-HSA-419166
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Rho guanyl-nucleotide exchange factor activity of GEFs [cytosol] GEFs [cytosol] Rho guanyl-nucleotide exchange factor activity (0005089)
Orthologous Events