GEFs activate RhoA,B,C

Stable Identifier
R-HSA-419166
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

Literature References
PubMed ID Title Journal Year
16212495 Rho GTPases: biochemistry and biology Annu Rev Cell Dev Biol 2005
9308960 Rho GTPases and signaling networks Genes Dev 1997
12101119 Guanine nucleotide exchange factors for Rho GTPases: turning on the switch Genes Dev 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of GEFs [cytosol]
Physical Entity
Activity
Orthologous Events