Reactome | MYH9 [cytosol]

MYH9 [cytosol]

Stable Identifier

R-HSA-419173

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin-9, MYH9_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH9 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH9 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH9 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35579 MYH9

Gene Names

MYH9

Chain

initiator methionine:1, chain:2-1960

Reference Genes

BioGPS Gene:4627 MYH9

COSMIC (genes):MYH9 MYH9

CTD Gene:4627 MYH9

dbSNP Gene:4627 MYH9

ENSEMBL:ENSG00000100345 MYH9

HGNC:7579 MYH9

KEGG Gene (Homo sapiens):4627 MYH9

Monarch:4627 MYH9

NCBI Gene:4627 MYH9

OMIM:160775 MYH9

UCSC:P35579 MYH9

Reference Transcript

Other Identifiers

0002450184

11739009_a_at

11739010_a_at

11752051_a_at

11752052_x_at

16934491

211926_s_at

3959452

3959453

3959454

3959455

3959456

3959457

3959458

3959459

3959460

3959461

3959463

3959464

3959465

3959466

3959467

3959468

3959470

3959471

3959472

3959473

3959474

3959475

3959476

3959479

3959480

3959482

3959483

3959484

3959485

3959486

3959489

3959490

3959491

3959493

3959494

3959496

3959498

3959501

3959504

3959505

3959509

3959513

3959514

3959515

3959518

3959520

3959521

3959523

3959524

3959526

3959528

3959534

3959535

3959551

3959552

3959558

3959568

39738_at

4627

72983_at

8075728

A_23_P57497

A_24_P408424

A_33_P3353692

GE81161

GE88562

GO:0000003

GO:0000146

GO:0000166

GO:0000212

GO:0000902

GO:0000904

GO:0001525

GO:0001701

GO:0001725

GO:0001726

GO:0001768

GO:0001772

GO:0001778

GO:0001931

GO:0002376

GO:0003674

GO:0003723

GO:0003774

GO:0003779

GO:0005178

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005819

GO:0005826

GO:0005829

GO:0005856

GO:0005886

GO:0005903

GO:0005912

GO:0005925

GO:0005938

GO:0006509

GO:0006810

GO:0006911

GO:0006950

GO:0007009

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007229

GO:0007520

GO:0008092

GO:0008150

GO:0008180

GO:0008360

GO:0009790

GO:0015031

GO:0015629

GO:0016020

GO:0016192

GO:0016459

GO:0016460

GO:0016887

GO:0019904

GO:0030048

GO:0030154

GO:0030220

GO:0030224

GO:0030674

GO:0030863

GO:0030898

GO:0031032

GO:0031252

GO:0031532

GO:0031594

GO:0032154

GO:0032418

GO:0032506

GO:0032796

GO:0032991

GO:0040011

GO:0042641

GO:0042803

GO:0043167

GO:0043226

GO:0043495

GO:0043531

GO:0043534

GO:0045055

GO:0045296

GO:0048646

GO:0048856

GO:0048870

GO:0050900

GO:0051015

GO:0051295

GO:0051301

GO:0051604

GO:0061024

GO:0070062

GO:0070527

GO:0097513

GO:0098609

GO:1903919

GO:1903923

GO:1905684

Hs.146550.0.A2_3p_a_at

ILMN_1722872

ILMN_2087702

M31013_at

PH_hs_0031821

TC22000703.hg

TC22001326.hg

Participant Of

hasComponent

sCD163:MYH9 [cytosol]

input

sCD163 binds MYH9 in T-cells

hasCandidate

Myosin [cytosol]

hasMember

Smooth muscle/non-muscle myosin 2 heavy chains [cytosol]

This entity regulates

Positively

SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane

Inferred To

MYO1 [cytosol] (Saccharomyces cerevisiae)

Myh9 [cytosol] (Mus musculus)

Myh9 [cytosol] (Rattus norvegicus)

myo2 [cytosol] (Schizosaccharomyces pombe)

zip [cytosol] (Drosophila melanogaster)

myh9 [cytosol] (Xenopus tropicalis)

myo3 [cytosol] (Schizosaccharomyces pombe)

nmy-1 [cytosol] (Caenorhabditis elegans)

MYH9 [cytosol] (Bos taurus)

MYH9 [cytosol] (Sus scrofa)

mhcA [cytosol] (Dictyostelium discoideum)

Homologues of MYH9 [cytosol] (Caenorhabditis elegans)

Homologues of MYH9 [cytosol] (Schizosaccharomyces pombe)

nmy-2 [cytosol] (Caenorhabditis elegans)

myh9b [cytosol] (Danio rerio)

Cross References

RefSeq

XP_016884294.1, XP_016884295.1, NP_002464.1, XP_011528499.1, XP_016884292.1, XP_016884293.1

OpenTargets

ENSG00000100345

HPA

ENSG00000100345-MYH9

GeneCards

P35579

Ensembl

ENST00000216181, ENSG00000100345, ENSP00000216181

PRO

P35579

Orphanet

16503

PDB

2LNK, 4ETO, 4CFQ, 3ZWH, 4CFR

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26447 S10A4			0.785	11
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	3
UniProt:O46385 SVIL			0.609	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:P61073 CXCR4	1	CXCR4 [plasma membrane] (R-HSA-2980772)	0.556	5
UniProt:O00255 MEN1	4	MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [cytosol] (R-HSA-5672315) MEN1 [nucleoplasm] (R-HSA-2186626)	0.556	3
UniProt:O00255-2 MEN1			0.544	4
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.463	3
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2