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MYH9 [cytosol]
Stable Identifier
R-HSA-419173
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Myosin-9, MYH9_HUMAN
Locations in the PathwayBrowser for interactor 1-phosphatidyl-1D-myo-inositol
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
CD163 mediating an anti-inflammatory response (Homo sapiens)
sCD163 binds MYH9 in T-cells (Homo sapiens)
MYH9 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)
MYH9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35579 MYH9
Gene Names
MYH9
Chain
initiator methionine:1, chain:2-1960
Reference Genes
BioGPS Gene:4627 MYH9
COSMIC (genes):MYH9 MYH9
CTD Gene:4627 MYH9
dbSNP Gene:4627 MYH9
ENSEMBL:ENSG00000100345 MYH9
HGNC:7579 MYH9
KEGG Gene (Homo sapiens):4627 MYH9
Monarch:4627 MYH9
NCBI Gene:4627 MYH9
OMIM:160775 MYH9
UCSC:P35579 MYH9
Reference Transcript
RefSeq:XM_017028805.1 MYH9
RefSeq:XM_017028803.1 MYH9
RefSeq:XM_017028806.1 MYH9
RefSeq:NM_002473.5 MYH9
RefSeq:XM_011530197.2 MYH9
RefSeq:XM_017028804.1 MYH9
Other Identifiers
0002450184
11739009_a_at
11739010_a_at
11752051_a_at
11752052_x_at
16934491
211926_s_at
3959452
3959453
3959454
3959455
3959456
3959457
3959458
3959459
3959460
3959461
3959463
3959464
3959465
3959466
3959467
3959468
3959470
3959471
3959472
3959473
3959474
3959475
3959476
3959479
3959480
3959482
3959483
3959484
3959485
3959486
3959489
3959490
3959491
3959493
3959494
3959496
3959498
3959501
3959504
3959505
3959509
3959513
3959514
3959515
3959518
3959520
3959521
3959523
3959524
3959526
3959528
3959534
3959535
3959551
3959552
3959558
3959568
39738_at
4627
72983_at
8075728
A_23_P57497
A_24_P408424
A_33_P3353692
GE81161
GE88562
GO:0000003
GO:0000146
GO:0000166
GO:0000212
GO:0000902
GO:0000904
GO:0001525
GO:0001701
GO:0001725
GO:0001726
GO:0001768
GO:0001772
GO:0001778
GO:0001931
GO:0002376
GO:0003674
GO:0003723
GO:0003774
GO:0003779
GO:0005178
GO:0005515
GO:0005516
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005819
GO:0005826
GO:0005829
GO:0005856
GO:0005886
GO:0005903
GO:0005912
GO:0005925
GO:0005938
GO:0006509
GO:0006810
GO:0006911
GO:0006950
GO:0007009
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0007229
GO:0007520
GO:0008092
GO:0008150
GO:0008180
GO:0008360
GO:0009790
GO:0015031
GO:0015629
GO:0016020
GO:0016192
GO:0016459
GO:0016460
GO:0016887
GO:0019904
GO:0030048
GO:0030154
GO:0030220
GO:0030224
GO:0030674
GO:0030863
GO:0030898
GO:0031032
GO:0031252
GO:0031532
GO:0031594
GO:0032154
GO:0032418
GO:0032506
GO:0032796
GO:0032991
GO:0040011
GO:0042641
GO:0042803
GO:0043167
GO:0043226
GO:0043495
GO:0043531
GO:0043534
GO:0045055
GO:0045296
GO:0048646
GO:0048856
GO:0048870
GO:0050900
GO:0051015
GO:0051295
GO:0051301
GO:0051604
GO:0061024
GO:0070062
GO:0070527
GO:0097513
GO:0098609
GO:1903919
GO:1903923
GO:1905684
Hs.146550.0.A2_3p_a_at
ILMN_1722872
ILMN_2087702
M31013_at
PH_hs_0031821
TC22000703.hg
TC22001326.hg
Participant Of
hasComponent
sCD163:MYH9 [cytosol]
input
sCD163 binds MYH9 in T-cells
hasCandidate
Myosin [cytosol]
hasMember
Smooth muscle/non-muscle myosin 2 heavy chains [cytosol]
This entity regulates
Positively
SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
Inferred To
MYO1 [cytosol] (Saccharomyces cerevisiae)
Myh9 [cytosol] (Mus musculus)
Myh9 [cytosol] (Rattus norvegicus)
myo2 [cytosol] (Schizosaccharomyces pombe)
zip [cytosol] (Drosophila melanogaster)
myh9 [cytosol] (Xenopus tropicalis)
myo3 [cytosol] (Schizosaccharomyces pombe)
nmy-1 [cytosol] (Caenorhabditis elegans)
MYH9 [cytosol] (Sus scrofa)
mhcA [cytosol] (Dictyostelium discoideum)
Homologues of MYH9 [cytosol] (Caenorhabditis elegans)
Homologues of MYH9 [cytosol] (Schizosaccharomyces pombe)
nmy-2 [cytosol] (Caenorhabditis elegans)
myh9b [cytosol] (Danio rerio)
Cross References
RefSeq
NP_002464.1
,
XP_016884294.1
,
XP_011528499.1
,
XP_016884293.1
,
XP_016884292.1
,
XP_016884295.1
Target Pathogen
5b354852be737e166372e68a
OpenTargets
ENSG00000100345
HPA
ENSG00000100345-MYH9
GeneCards
P35579
Ensembl
ENST00000216181
,
ENSP00000216181
,
ENSG00000100345
PRO
P35579
Orphanet
16503
PDB
3ZWH
,
4CFR
,
4ETO
,
2LNK
,
4CFQ
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26447 S10A4
0.842
13
UniProt:P25815 S100P
2
S100P [secretory granule lumen]
(R-HSA-6804782)
S100P [extracellular region]
(R-HSA-6804809)
0.676
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.659
3
UniProt:P23297 S100A1
1
S100A1 [extracellular region]
(R-HSA-6805991)
0.611
3
UniProt:P35579 MYH9
1
MYH9 [cytosol]
(R-HSA-419173)
0.609
8
UniProt:O46385 SVIL
0.609
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.597
3
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.556
5
UniProt:O00255 MEN1
4
MEN1 [endoplasmic reticulum lumen]
(R-HSA-8956785)
p-MEN1 [endoplasmic reticulum lumen]
(R-HSA-8956901)
MEN1 [cytosol]
(R-HSA-5672315)
MEN1 [nucleoplasm]
(R-HSA-2186626)
0.556
3
UniProt:P33763 S10A5
0.544
2
UniProt:P29034 S10A2
0.544
2
UniProt:O00255-2 MEN1
0.544
4
UniProt:P06703 S10A6
0.544
2
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.544
2
UniProt:Q92731 ESR2
5
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.527
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
9
UniProt:P19338 NCL
1
NCL [nucleoplasm]
(R-HSA-6791213)
0.463
3
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
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