Reactome | MYL6 [cytosol]

MYL6 [cytosol]

Stable Identifier

R-HSA-419186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin light polypeptide 6, MYL6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60660 MYL6

Gene Names

MYL6

Chain

initiator methionine:1, chain:2-151

Reference Genes

BioGPS Gene:4637 MYL6

COSMIC (genes):MYL6 MYL6

CTD Gene:4637 MYL6

dbSNP Gene:4637 MYL6

ENSEMBL:ENSG00000092841 MYL6

HGNC:7587 MYL6

KEGG Gene (Homo sapiens):4637 MYL6

Monarch:4637 MYL6

NCBI Gene:4637 MYL6

OMIM:609931 MYL6

UCSC:P60660 MYL6

Reference Transcript

Other Identifiers

0000770079

11716794_a_at

11747439_a_at

212082_s_at

214002_at

33994_g_at

3417454

3417458

3417462

3417465

3417466

3417467

3417469

3417471

3417473

3417474

3417475

3417476

3417477

4637

46859

63034

7956211

89570_f_at

A_23_P344973

A_24_P56130

AAA20643

AAA36347

AAA36348

AAA59853

AAA59892

AAA59893

AAH06781

AAH17455

AAH71661

AAH93066

AB046613

B7Z6Z4

BAB62402

BC006781

BC017455

BC071661

BC093066

CAG33295

CCDS31834

CCDS8906

CR457014

ENSG00000092841

ENSP00000446714

ENSP00000446955

ENSP00000448101

ENST00000547649

ENST00000547649.5

ENST00000548293

ENST00000548293.5

ENST00000550697

ENST00000550697.5

EntrezGene:4637

EntrezGene:MYL6

F8VPF3

F8VXL3

F8VZU9

F8W180

F8W1R7

G3V1V0

G3V1Y7

G8JLA2

GE499816

GE82578

GO:0003674

GO:0003774

GO:0005198

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0005903

GO:0006936

GO:0007519

GO:0008150

GO:0008307

GO:0016020

GO:0016459

GO:0016461

GO:0016887

GO:0030049

GO:0030898

GO:0031982

GO:0032991

GO:0043167

GO:0043226

GO:0048856

GO:0070062

HGNC:7587

HPA046859

HPA063034

Hs.77385.2.S1_3p_a_at

Hs.77385.2.S1_3p_x_at

Hs.77385.3.S1_3p_a_at

Hs.77385.3.S1_3p_x_at

ILMN_1809013

ILMN_2326071

IPR002048

IPR011992

J3KND3

M22918

M22919

M22920

M31212

MIM:609931

MYL6

MYL6-207

MYL6-209

MYL6-218

NM_021019

NM_079423

NP_066299

NP_524147

PF13405

PH_hs_0035463

SM00054

TC12003245.hg

U02629

UPI0000000C7D

UPI0000000E0D

Participant Of

hasMember

Smooth Muscle Myosin Light Chain [cytosol]

hasComponent

Other forms of this molecule

p-S20-MYL6 [cytosol]

Inferred To

Mlc-c [cytosol] (Drosophila melanogaster)

mlcE [cytosol] (Dictyostelium discoideum)

cal-7 [cytosol] (Caenorhabditis elegans)

Homologues of MYL6 [cytosol] (Caenorhabditis elegans)

Homologues of MYL6 [cytosol] (Drosophila melanogaster)

Homologues of MYL6 [cytosol] (Plasmodium falciparum)

MYL6 [cytosol] (Bos taurus)

MYL6 [cytosol] (Danio rerio)

MYL6 [cytosol] (Gallus gallus)

MYL6 [cytosol] (Plasmodium falciparum)

MYL6 [cytosol] (Sus scrofa)

Mlc1 [cytosol] (Drosophila melanogaster)

MLC1 [cytosol] (Saccharomyces cerevisiae)

mlc-6 [cytosol] (Caenorhabditis elegans)

cdc4 [cytosol] (Schizosaccharomyces pombe)

mlc-5 [cytosol] (Caenorhabditis elegans)

Myl6 [cytosol] (Mus musculus)

Ghost homologue of MYL6 [cytosol] (Rattus norvegicus)

mlc-7 [cytosol] (Caenorhabditis elegans)

myl6 [cytosol] (Xenopus tropicalis)

mlc-3 [cytosol] (Caenorhabditis elegans)

Dmel\CG17237 [cytosol] (Drosophila melanogaster)

Dmel\CG34435 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_066299.2, NP_524147.2

Target Pathogen

5b354852be737e166372e989

OpenTargets

ENSG00000092841

GeneCards

P60660

HPA

ENSG00000092841-MYL6

Ensembl

ENSG00000092841, ENST00000548293, ENST00000550697, ENST00000547649, ENSP00000448101, ENSP00000446955, ENSP00000446714

PRO

P60660

HMDB Protein

HMDBP07824

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.642	3
UniProt:Q14164 IKBKE	4	p-S172-IKBKE [endosome membrane] (R-HSA-450278) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.508	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2

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