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MYL6 [cytosol]
Stable Identifier
R-HSA-419186
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Myosin light polypeptide 6, MYL6_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
Activated ROCK phosphorylates MRLCs (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19-MRLC-Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60660 MYL6
Gene Names
MYL6
Chain
initiator methionine:, chain:2-151
Reference Genes
COSMIC (genes):MYL6 MYL6
dbSNP Gene:4637 MYL6
ENSEMBL:ENSG00000092841 MYL6
Participates
as a member of
Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
as a component of
p-T19-MRLC-Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
Other forms of this molecule
p-S20-MYL6 [cytosol]
Inferred To
Myl6 [cytosol]
(Mus musculus)
Myl6 [cytosol]
(Rattus norvegicus)
cal-7 [cytosol]
(Caenorhabditis elegans)
Homologues of MYL6 [cytosol]
(Caenorhabditis elegans)
Homologues of MYL6 [cytosol]
(Drosophila melanogaster)
Homologues of MYL6 [cytosol]
(Plasmodium falciparum)
MYL6 [cytosol]
(Bos taurus)
MYL6 [cytosol]
(Dictyostelium discoideum)
MYL6 [cytosol]
(Drosophila melanogaster)
MYL6 [cytosol]
(Gallus gallus)
MYL6 [cytosol]
(Plasmodium falciparum)
MYL6 [cytosol]
(Saccharomyces cerevisiae)
MYL6 [cytosol]
(Schizosaccharomyces pombe)
MYL6 [cytosol]
(Sus scrofa)
mlc-7 [cytosol]
(Caenorhabditis elegans)
myl6 [cytosol]
(Xenopus tropicalis)
mlc-6 [cytosol]
(Caenorhabditis elegans)
mlc-3 [cytosol]
(Caenorhabditis elegans)
mlc-5 [cytosol]
(Caenorhabditis elegans)
Dmel\CG17237 [cytosol]
(Drosophila melanogaster)
Dmel\CG34435 [cytosol]
(Drosophila melanogaster)
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.643
6
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.642
3
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.638
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
19
UniProt:Q14164 IKBKE
5
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.589
2
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.527
3
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.527
2
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