Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MYL6 [cytosol]
Stable Identifier
R-HSA-419186
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Myosin light polypeptide 6, MYL6_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
Activated ROCK phosphorylates MRLCs (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19-MRLC-Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
MYL6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60660 MYL6
Gene Names
MYL6
Chain
initiator methionine:, chain:2-151
Reference Genes
BioGPS Gene:4637 MYL6
COSMIC (genes):MYL6 MYL6
CTD Gene:4637 MYL6
dbSNP Gene:4637 MYL6
ENSEMBL:ENSG00000092841 MYL6
ENSEMBL_homo_sapiens_GENE:ENSG00000092841.19 MYL6
HGNC:7587 MYL6
KEGG Gene (Homo sapiens):4637 MYL6
Monarch:4637 MYL6
NCBI Gene:4637 MYL6
OMIM:609931 MYL6
UCSC:P60660 MYL6
Reference Transcript
RefSeq:NM_021019.4 MYL6
RefSeq:NM_079423.3 MYL6
Other Identifiers
11716794_a_at
11747439_a_at
212082_PM_s_at
212082_s_at
214002_PM_at
214002_at
33994_g_at
3417458
3417462
3417465
3417466
3417467
3417469
3417471
3417473
3417474
3417475
3417476
3417477
4637
7956211
89570_f_at
A_23_P344973
GE499816
GO:0000146
GO:0003012
GO:0003774
GO:0005198
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0005856
GO:0005903
GO:0006936
GO:0007519
GO:0008307
GO:0016020
GO:0016459
GO:0016460
GO:0016461
GO:0030049
GO:0031982
GO:0043226
GO:0048856
GO:0070062
GO:0140657
HMNXSV003035280
Hs.77385.2.S1_3p_a_at
Hs.77385.2.S1_3p_x_at
Hs.77385.3.S1_3p_a_at
Hs.77385.3.S1_3p_x_at
ILMN_1809013
ILMN_2326071
PH_hs_0035463
p33402
Participates
as a member of
Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
as a component of
p-T19-MRLC-Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
Other forms of this molecule
p-S20-MYL6 [cytosol]
Inferred To
Myl6 [cytosol]
(Mus musculus)
Myl6 [cytosol]
(Rattus norvegicus)
cal-7 [cytosol]
(Caenorhabditis elegans)
Homologues of MYL6 [cytosol]
(Caenorhabditis elegans)
Homologues of MYL6 [cytosol]
(Drosophila melanogaster)
Homologues of MYL6 [cytosol]
(Plasmodium falciparum)
MYL6 [cytosol]
(Bos taurus)
MYL6 [cytosol]
(Dictyostelium discoideum)
MYL6 [cytosol]
(Drosophila melanogaster)
MYL6 [cytosol]
(Gallus gallus)
MYL6 [cytosol]
(Plasmodium falciparum)
MYL6 [cytosol]
(Saccharomyces cerevisiae)
MYL6 [cytosol]
(Schizosaccharomyces pombe)
MYL6 [cytosol]
(Sus scrofa)
mlc-7 [cytosol]
(Caenorhabditis elegans)
myl6 [cytosol]
(Xenopus tropicalis)
mlc-6 [cytosol]
(Caenorhabditis elegans)
mlc-3 [cytosol]
(Caenorhabditis elegans)
mlc-5 [cytosol]
(Caenorhabditis elegans)
Dmel\CG17237 [cytosol]
(Drosophila melanogaster)
Dmel\CG34435 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_524147.2
,
NP_066299.2
OpenTargets
ENSG00000092841
HPA
ENSG00000092841-MYL6
GeneCards
P60660
Ensembl
ENST00000548293
,
ENSP00000446714
,
ENSP00000446955
,
ENST00000550697
,
ENSG00000092841
,
ENSP00000448101
,
ENST00000547649
PRO
P60660
Pharos - Targets
P60660
HMDB Protein
HMDBP07824
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.642
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
19
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.589
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.527
2
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text