Reactome | MYL6 [cytosol]

MYL6 [cytosol]

Stable Identifier

R-HSA-419186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin light polypeptide 6, MYL6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P60660 MYL6

Gene Names

MYL6

Chain

initiator methionine:1, chain:2-151

Reference Genes

BioGPS Gene:4637 MYL6

COSMIC (genes):MYL6 MYL6

CTD Gene:4637 MYL6

dbSNP Gene:4637 MYL6

ENSEMBL:ENSG00000092841 MYL6

HGNC:7587 MYL6

KEGG Gene (Homo sapiens):4637 MYL6

Monarch:4637 MYL6

NCBI Gene:4637 MYL6

OMIM:609931 MYL6

UCSC:P60660 MYL6

Reference Transcript

Other Identifiers

0000770079

11716794_a_at

11747439_a_at

212082_s_at

214002_at

33994_g_at

3417458

3417462

3417465

3417466

3417467

3417469

3417471

3417473

3417474

3417475

3417476

3417477

4637

7956211

89570_f_at

A_23_P344973

GE499816

GO:0003674

GO:0003774

GO:0005198

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005903

GO:0006936

GO:0007519

GO:0008150

GO:0008307

GO:0016020

GO:0016459

GO:0016461

GO:0016887

GO:0030049

GO:0030898

GO:0031982

GO:0032991

GO:0043167

GO:0043226

GO:0048856

GO:0070062

HMNXSV003035280

Hs.77385.2.S1_3p_a_at

Hs.77385.2.S1_3p_x_at

Hs.77385.3.S1_3p_a_at

Hs.77385.3.S1_3p_x_at

ILMN_1809013

ILMN_2326071

PH_hs_0035463

Participates

as a member of

Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

p-S20-MYL6 [cytosol]

Inferred To

Mlc-c [cytosol] (Drosophila melanogaster)

mlcE [cytosol] (Dictyostelium discoideum)

cal-7 [cytosol] (Caenorhabditis elegans)

Homologues of MYL6 [cytosol] (Caenorhabditis elegans)

Homologues of MYL6 [cytosol] (Canis familiaris)

Homologues of MYL6 [cytosol] (Danio rerio)

Homologues of MYL6 [cytosol] (Drosophila melanogaster)

Homologues of MYL6 [cytosol] (Plasmodium falciparum)

Homologues of MYL6 [cytosol] (Sus scrofa)

MYL6 [cytosol] (Canis familiaris)

MYL6 [cytosol] (Danio rerio)

MYL6 [cytosol] (Gallus gallus)

MYL6 [cytosol] (Plasmodium falciparum)

MYL6 [cytosol] (Sus scrofa)

Mlc1 [cytosol] (Drosophila melanogaster)

MLC1 [cytosol] (Saccharomyces cerevisiae)

mlc-6 [cytosol] (Caenorhabditis elegans)

cdc4 [cytosol] (Schizosaccharomyces pombe)

mlc-5 [cytosol] (Caenorhabditis elegans)

Myl6 [cytosol] (Mus musculus)

Myl6 [cytosol] (Rattus norvegicus)

mlc-7 [cytosol] (Caenorhabditis elegans)

myl6 [cytosol] (Danio rerio)

mlc-3 [cytosol] (Caenorhabditis elegans)

Dmel\CG17237 [cytosol] (Drosophila melanogaster)

MYL6B [cytosol] (Sus scrofa)

Dmel\CG34435 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_066299.2, NP_524147.2

Target Pathogen

5b354852be737e166372e989

OpenTargets

ENSG00000092841

GeneCards

P60660

HPA

ENSG00000092841-MYL6

Ensembl

ENSG00000092841, ENST00000548293, ENST00000547649, ENST00000550697, ENSP00000446714, ENSP00000446955, ENSP00000448101

PRO

P60660

HMDB Protein

HMDBP07824

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.642	3
UniProt:Q14164 IKBKE	4	p-S172-IKBKE [cytosol] (R-HSA-450278) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.508	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2

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