Reactome | FANCC [nucleoplasm]

FANCC [nucleoplasm]

Stable Identifier

R-HSA-419530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group C protein, FANCC_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        TP53 stimulates FANCC expression (Homo sapiens)
        
        FANCC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00597 FANCC

Gene Names

FANCC, FAC, FACC

Chain

chain:1-558

Reference Genes

BioGPS Gene:2176 FANCC

COSMIC (genes):FANCC FANCC

CTD Gene:2176 FANCC

dbSNP Gene:2176 FANCC

ENSEMBL:ENSG00000158169 FANCC

HGNC:3584 FANCC

KEGG Gene (Homo sapiens):2176 FANCC

Monarch:2176 FANCC

NCBI Gene:2176 FANCC

OMIM:613899 FANCC

UCSC:Q00597 FANCC

Reference Transcript

Other Identifiers

0005080079

11721591_a_at

11721592_a_at

11756738_a_at

160034_s_at

17096054

1982_s_at

205189_s_at

2176

3215716

3215717

3215718

3215719

3215720

3215721

3215722

3215723

3215724

3215727

3215732

3215733

3215735

3215736

3215741

3215742

3215752

3215753

3215761

3215763

3215764

3215765

3215787

3215789

3215790

3215791

3215800

3215802

35713_at

72202_f_at

8162514

A_23_P32021

GE59932

GO:0000003

GO:0002262

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006289

GO:0006950

GO:0006974

GO:0007276

GO:0007281

GO:0008150

GO:0019430

GO:0022607

GO:0030154

GO:0032991

GO:0034599

GO:0034641

GO:0036297

GO:0042592

GO:0043226

GO:0043240

GO:0048854

GO:0048856

GO:0065003

GO:0097150

ILMN_1683112

PH_hs_0023250

TC09001361.hg

X66894_s_at

g4557588_3p_a_at

Participant Of

output

TP53 stimulates FANCC expression

input

FA core complex assembles at DNA interstrand crosslinks (ICLs)

hasComponent

Inferred To

Ghost homologue of FANCC [nucleoplasm] (Bos taurus)

FANCC [nucleoplasm] (Canis familiaris)

FANCC [nucleoplasm] (Gallus gallus)

FANCC [nucleoplasm] (Sus scrofa)

Fancc [nucleoplasm] (Mus musculus)

Fancc [nucleoplasm] (Rattus norvegicus)

fancc [nucleoplasm] (Danio rerio)

fancc [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_000127.2, XP_011516667.1, NP_001230672.1

OpenTargets

ENSG00000158169

HPA

ENSG00000158169-FANCC

GeneCards

Q00597

Ensembl

ENSP00000364454, ENSG00000158169, ENSP00000289081, ENST00000289081, ENST00000375305

PRO

Q00597

Orphanet

16022

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HB96 FANCE	1	FANCE [nucleoplasm] (R-HSA-419543)	0.721	5
UniProt:Q13813 SPTAN1	6	SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533)	0.589	2
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.581	4
UniProt:O15360 FANCA	1	FANCA [nucleoplasm] (R-HSA-419541)	0.573	2
UniProt:Q6FHY5 Q6FHY5			0.556	3

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