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FANCC [nucleoplasm]
Stable Identifier
R-HSA-419530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi anemia group C protein, FANCC_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
Monoubiquitination of FANCD2:FANCI (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
TP53 stimulates FANCC expression (Homo sapiens)
FANCC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00597 FANCC
Gene Names
FANCC, FAC, FACC
Chain
chain:1-558
Reference Genes
BioGPS Gene:2176 FANCC
COSMIC (genes):FANCC FANCC
CTD Gene:2176 FANCC
dbSNP Gene:2176 FANCC
ENSEMBL:ENSG00000158169 FANCC
HGNC:3584 FANCC
KEGG Gene (Homo sapiens):2176 FANCC
Monarch:2176 FANCC
NCBI Gene:2176 FANCC
OMIM:613899 FANCC
UCSC:Q00597 FANCC
Reference Transcript
RefSeq:NM_000136.2 FANCC
RefSeq:NM_001243743.1 FANCC
RefSeq:XM_011518365.2 FANCC
Other Identifiers
0005080079
11721591_a_at
11721592_a_at
11756738_a_at
160034_s_at
17096054
1982_s_at
205189_s_at
2176
3215716
3215717
3215718
3215719
3215720
3215721
3215722
3215723
3215724
3215727
3215732
3215733
3215735
3215736
3215741
3215742
3215752
3215753
3215761
3215763
3215764
3215765
3215787
3215789
3215790
3215791
3215800
3215802
35713_at
72202_f_at
8162514
A_23_P32021
GE59932
GO:0000003
GO:0002262
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006281
GO:0006289
GO:0006950
GO:0006974
GO:0007276
GO:0007281
GO:0008150
GO:0019430
GO:0022607
GO:0030154
GO:0032991
GO:0034599
GO:0034641
GO:0036297
GO:0042592
GO:0043226
GO:0043240
GO:0048854
GO:0048856
GO:0065003
GO:0097150
HMNXSV003009246
HMNXSV003015010
HMNXSV003023258
ILMN_1683112
PH_hs_0023250
TC09001361.hg
X66894_s_at
g4557588_3p_a_at
Participates
as a component of
FA core complex [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
as an output of
TP53 stimulates FANCC expression (Homo sapiens)
as an input of
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
Inferred To
Ghost homologue of FANCC [nucleoplasm]
(Bos taurus)
Ghost homologue of FANCC [nucleoplasm]
(Sus scrofa)
FANCC [nucleoplasm]
(Canis familiaris)
FANCC [nucleoplasm]
(Gallus gallus)
Fancc [nucleoplasm]
(Mus musculus)
Fancc [nucleoplasm]
(Rattus norvegicus)
fancc [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001230672.1
,
NP_000127.2
,
XP_011516667.1
OpenTargets
ENSG00000158169
GeneCards
Q00597
HPA
ENSG00000158169-FANCC
Ensembl
ENSP00000289081
,
ENST00000289081
,
ENSP00000364454
,
ENSG00000158169
,
ENST00000375305
PRO
Q00597
Orphanet
16022
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HB96 FANCE
1
FANCE [nucleoplasm]
(R-HSA-419543)
0.721
5
UniProt:Q13813 SPTAN1
6
SPTAN1(1-1185) [cytosol]
(R-HSA-202944)
SPTAN1 [cytosol]
(R-HSA-201601)
SPTAN1(1186-2472) [cytosol]
(R-HSA-202964)
SPTAN1 [specific granule lumen]
(R-HSA-6799533)
SPTAN1 [extracellular region]
(R-HSA-6806322)
SPTAN1 [tertiary granule lumen]
(R-HSA-6800874)
0.589
2
UniProt:P14625 HSP90B1
4
HSP90B1 [extracellular region]
(R-HSA-3221653)
HSP90B1 [endocytic vesicle lumen]
(R-HSA-3221623)
p-HSP90B1 [endoplasmic reticulum lumen]
(R-HSA-8957016)
HSP90B1 [endoplasmic reticulum lumen]
(R-HSA-981545)
0.581
4
UniProt:O15360 FANCA
1
FANCA [nucleoplasm]
(R-HSA-419541)
0.573
2
UniProt:Q6FHY5 Q6FHY5
0.556
3
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