Reactome | FANCC [nucleoplasm]

FANCC

Stable Identifier

R-HSA-419530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group C protein, FANCC_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        TP53 stimulates FANCC expression (Homo sapiens)
        
        FANCC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00597 FANCC

Gene Names

FANCC, FAC, FACC

Chain

chain:1-558

Reference Genes

BioGPS Gene:2176 FANCC

COSMIC (genes):FANCC FANCC

CTD Gene:2176 FANCC

dbSNP Gene:2176 FANCC

ENSEMBL:ENSG00000158169 FANCC

HGNC:3584 FANCC

KEGG Gene (Homo sapiens):hsa:2176 FANCC

Monarch:2176 FANCC

NCBI Gene:2176 FANCC

OMIM:613899 FANCC

UCSC:Q00597 FANCC

Reference Transcript

Other Identifiers

0005080079

11721591_a_at

11721592_a_at

11756738_a_at

160034_s_at

17096054

17793

1982_s_at

205189_s_at

2176

30771

35713_at

72202_f_at

8162514

A0A024R9N2

A_23_P32021

CAB017793

CCDS35071

ENSG00000158169

ENSP00000289081

ENSP00000364454

ENST00000289081

ENST00000375305

EntrezGene:2176

FANCC

FANCC-201

FANCC-202

g4557588_3p_a_at

GE59932

GO:0002262

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006289

GO:0006461

GO:0006974

GO:0007276

GO:0007281

GO:0019430

GO:0034599

GO:0036297

GO:0043240

GO:0048854

GO:0097150

HGNC:3584

HPA030771

Hs.494529

ILMN_1683112

LRG_497

LRG_497t1

MIM:189960

MIM:227645

MIM:613899

NM_000136

NM_001243743

NP_000127

NP_001230672

PF02106

PH_hs_0023250

PR00494

TC09001361.hg

uc004avh.4

uc022bkl.2

UPI000000D910

X66894_s_at

XM_006717001

XM_011518365

XM_011518367

XM_017014452

XM_017014453

XM_017014454

XP_006717064

XP_011516667

XP_011516669

XP_016869941

XP_016869942

XP_016869943

Participant Of

input

FA core complex assembles at DNA interstrand crosslinks (ICLs)

hasComponent

output

TP53 stimulates FANCC expression

Inferred To

FANCC [nucleoplasm] (Bos taurus)

FANCC [nucleoplasm] (Canis familiaris)

FANCC [nucleoplasm] (Danio rerio)

FANCC [nucleoplasm] (Gallus gallus)

FANCC [nucleoplasm] (Mus musculus)

FANCC [nucleoplasm] (Rattus norvegicus)

FANCC [nucleoplasm] (Sus scrofa)

FANCC [nucleoplasm] (Taeniopygia guttata)

FANCC [nucleoplasm] (Xenopus tropicalis)

Homologues of FANCC [nucleoplasm] (Canis familiaris)

Homologues of FANCC [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_000127.2, NP_001230672.1, XP_011516667.1

GeneCards

Q00597

PRO

Q00597

Orphanet

16022

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HB96 FANCE	1	FANCE [nucleoplasm] (R-HSA-419543)	0.721	5
UniProt:Q13813 SPTAN1	6	SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1 [cytosol] (R-HSA-201601)	0.589	2
UniProt:P14625 HSP90B1	4	HSP90B1 [extracellular region] (R-HSA-3221653) HSP90B1 [endocytic vesicle lumen] (R-HSA-3221623) p-HSP90B1 [endoplasmic reticulum lumen] (R-HSA-8957016) HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.581	4
UniProt:O15360 FANCA	1	FANCA [nucleoplasm] (R-HSA-419541)	0.573	2
UniProt:Q6FHY5 Q6FHY5			0.556	3