Reactome | FANCG [nucleoplasm]

FANCG [nucleoplasm]

Stable Identifier

R-HSA-419532

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group G protein, FANCG_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P14079 TAX

Expand all

External Reference Information

External Reference

UniProt:O15287 FANCG

Gene Names

FANCG, XRCC9

Chain

chain:1-622

Reference Genes

BioGPS Gene:2189 FANCG

COSMIC (genes):FANCG FANCG

CTD Gene:2189 FANCG

dbSNP Gene:2189 FANCG

ENSEMBL:ENSG00000221829 FANCG

HGNC:3588 FANCG

KEGG Gene (Homo sapiens):2189 FANCG

Monarch:2189 FANCG

NCBI Gene:2189 FANCG

OMIM:602956 FANCG

Reference Transcript

RefSeq:NM_004629.1 FANCG

Other Identifiers

0002350487

11756256_a_at

17093595

203564_at

2189

3204120

3204464

3204465

3204467

3204468

3204469

3204472

3204475

3204476

3204477

3204478

3204479

3204480

3204482

3204483

3204485

3204486

3204487

3204488

3204489

3204490

3204492

3204493

3204494

3204495

37584_at

8160935

A_23_P71644

GE55181

GO:0000003

GO:0001541

GO:0003674

GO:0003677

GO:0003684

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006259

GO:0006281

GO:0006950

GO:0006974

GO:0007005

GO:0007286

GO:0008150

GO:0009314

GO:0030154

GO:0032991

GO:0034641

GO:0036297

GO:0043226

GO:0043240

GO:0048856

ILMN_1744900

ILMN_1758728

PH_hs_0025352

TC09001049.hg

g4759335_3p_at

Participant Of

hasComponent

input

FA core complex assembles at DNA interstrand crosslinks (ICLs)

Inferred To

PIGO [nucleoplasm] (Sus scrofa)

fancg [nucleoplasm] (Danio rerio)

FANCG [nucleoplasm] (Bos taurus)

FANCG [nucleoplasm] (Canis familiaris)

FANCG [nucleoplasm] (Gallus gallus)

FANCG [nucleoplasm] (Xenopus tropicalis)

Fancg [nucleoplasm] (Mus musculus)

Fancg [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_004620.1

OpenTargets

ENSG00000221829

HPA

ENSG00000221829-FANCG

GeneCards

O15287

Ensembl

ENSG00000221829, ENST00000378643, ENSP00000367910

PRO

O15287

Orphanet

16026

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15360 FANCA	1	FANCA [nucleoplasm] (R-HSA-419541)	0.951	16
UniProt:Q9NPI8 FANCF	1	FANCF [nucleoplasm] (R-HSA-419537)	0.75	6
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q99633 PRP18			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:P16284 PECAM1	4	p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P14079 TAX			0.556	3
UniProt:P60891 PRPS1	1	PRPS1 [cytosol] (R-HSA-73483)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [cytosol] (R-HSA-5625607) ATXN3 [nucleoplasm] (R-HSA-6783285)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q8N7U7-2 TPRX1			0.556	3
UniProt:P08684 CYP3A4	1	CYP3A4 [endoplasmic reticulum membrane] (R-HSA-52639)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P20339 RAB5A	6	RAB5A [endosome membrane] (R-HSA-452257) RAB5A [cytosol] (R-HSA-2201187) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:P29474 NOS3	7	MyrG-NOS3 [Golgi membrane] (R-HSA-534995) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) NOS3 [cytosol] (R-HSA-202114)	0.556	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q13393 PLD1	4	PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:Q86UD4 ZN329			0.556	3
UniProt:P14136 GFAP	3	GFAP [lysosomal membrane] (R-HSA-9625195) p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:Q8N6Y0 USBP1			0.553	2
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.553	2
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.553	2
UniProt:Q13813 SPTAN1	6	SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [tertiary granule lumen] (R-HSA-6800874) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [specific granule lumen] (R-HSA-6799533)	0.508	4
UniProt:P15976-2 GATA1			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:O15360-3 O153603			0.488	5
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.488	2
UniProt:P13646 KRT13	1	KRT13 [cytosol] (R-HSA-6809591)	0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.488	2
UniProt:Q7Z6G3-2 NECAB2			0.488	2
UniProt:Q8NA61-2 CBY2			0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q9Y2K1 ZBTB1			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:Q8N448 LNX2			0.488	2

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