Reactome | FANCA [nucleoplasm]

FANCA [nucleoplasm]

Stable Identifier

R-HSA-419541

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group A protein, FANCA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q0VG06 FAAP100

Expand all

External Reference Information

External Reference

UniProt:O15360 FANCA

Gene Names

FANCA, FAA, FACA, FANCH

Chain

chain:1-1455

Reference Genes

BioGPS Gene:2175 FANCA

COSMIC (genes):FANCA FANCA

CTD Gene:2175 FANCA

dbSNP Gene:2175 FANCA

ENSEMBL:ENSG00000187741 FANCA

HGNC:3582 FANCA

KEGG Gene (Homo sapiens):2175 FANCA

Monarch:2175 FANCA

NCBI Gene:2175 FANCA

OMIM:607139 FANCA

UCSC:O15360 FANCA

Reference Transcript

Other Identifiers

0004780341

0104540575

11729472_a_at

11729473_at

11729474_x_at

11730303_a_at

11730304_at

11730305_at

11748438_a_at

11753325_a_at

16829369

203805_s_at

203806_s_at

215530_at

2175

33145_at

3704978

3704979

3704981

3704982

3704983

3704984

3704986

3704987

3704989

3704990

3704993

3704996

3704997

3704998

3705000

3705001

3705003

3705005

3705008

3705009

3705011

3705012

3705013

3705014

3705017

3705018

3705021

3705024

3705025

3705027

3705028

3705030

3705031

3705032

3705033

3705035

3705036

3705037

3705038

3705039

3705040

3705043

3705044

3705045

3705046

3705047

3705048

3705049

3705051

3705053

3705054

3705055

3705056

3705057

3705058

3705059

3705061

3705062

3705064

3705065

3705068

8003503

82955_at

A_23_P206441

A_33_P3286422

A_33_P3386344

GE60215

GO:0000003

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0006259

GO:0006281

GO:0006950

GO:0006974

GO:0007049

GO:0007140

GO:0007165

GO:0008150

GO:0008283

GO:0008584

GO:0008585

GO:0009058

GO:0022607

GO:0030154

GO:0032991

GO:0034641

GO:0036297

GO:0042127

GO:0043226

GO:0043240

GO:0045589

GO:0048856

GO:0050727

GO:0051090

GO:0065003

GO:2000348

Hs.240138.0.S1_3p_at

Hs.240138.0.S1_3p_x_at

Hs.284153.0.A1_3p_a_at

ILMN_1682747

ILMN_1769758

ILMN_1799224

PH_hs_0014712

TC16001357.hg

X99226_at

g4503654_3p_a_at

Participant Of

hasComponent

input

FA core complex assembles at DNA interstrand crosslinks (ICLs)

Inferred To

LOC110438398 [nucleoplasm] (Danio rerio)

Fanca [nucleoplasm] (Mus musculus)

Fanca [nucleoplasm] (Rattus norvegicus)

FANCA [nucleoplasm] (Bos taurus)

FANCA [nucleoplasm] (Canis familiaris)

FANCA [nucleoplasm] (Gallus gallus)

FANCA [nucleoplasm] (Sus scrofa)

FANCA [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_000126.2, NP_001273096.1, NP_001018122.1

OpenTargets

ENSG00000187741

GeneCards

O15360

HPA

ENSG00000187741-FANCA

Ensembl

ENST00000389302, ENSG00000187741, ENST00000389301, ENST00000568369, ENSP00000456829, ENSP00000373952, ENSP00000373953

PRO

O15360

Orphanet

16020

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15287 FANCG	1	FANCG [nucleoplasm] (R-HSA-419532)	0.951	16
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.753	5
UniProt:Q9NW38 FANCL	1	FANCL [nucleoplasm] (R-HSA-419520)	0.597	3
UniProt:Q6NZ36-1 FAAP20			0.591	5
UniProt:Q00597 FANCC	1	FANCC [nucleoplasm] (R-HSA-419530)	0.573	2
UniProt:Q9NPI8 FANCF	1	FANCF [nucleoplasm] (R-HSA-419537)	0.573	5
UniProt:Q0VG06 FAAP100	1	FAAP100 [nucleoplasm] (R-HSA-419545)	0.558	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.543	3
UniProt:Q8IYD8 FANCM	2	FANCM [nucleoplasm] (R-HSA-419535) p-S1045-FANCM [nucleoplasm] (R-HSA-6788401)	0.527	3
UniProt:Q8NB91 FANCB	1	FANCB [nucleoplasm] (R-HSA-419528)	0.527	3

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