Reactome | FANCE [nucleoplasm]

FANCE [nucleoplasm]

Stable Identifier

R-HSA-419543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Fanconi anemia group E protein, FANCE_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BXW9 FANCD2

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External Reference Information

External Reference

UniProt:Q9HB96 FANCE

Gene Names

FANCE, FACE

Chain

chain:1-536

Reference Genes

BioGPS Gene:2178 FANCE

COSMIC (genes):FANCE FANCE

CTD Gene:2178 FANCE

dbSNP Gene:2178 FANCE

ENSEMBL:ENSG00000112039 FANCE

HGNC:3586 FANCE

KEGG:hsa:2178 FANCE

Monarch:2178 FANCE

NCBI Gene:2178 FANCE

OMIM:613976 FANCE

UCSC:Q9HB96 FANCE

Reference Transcript

RefSeq:NM_021922.2 FANCE

Other Identifiers

11733337_at

11733338_x_at

11733339_at

17007824

2178

220255_PM_at

220255_at

2904664

2904665

2904666

2904668

2904669

2904670

2904671

2904672

2904673

2904674

2904675

2904676

2904678

2904679

2904680

2904681

2904682

8118963

A_14_P103366

A_14_P104969

A_14_P121821

A_23_P42335

GE80787

GO:0000785

GO:0003674

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005813

GO:0005815

GO:0005829

GO:0006281

GO:0036297

GO:0043226

GO:0043240

HMNXSV003016853

HMNXSV003022276

ILMN_2043452

PH_hs_0015589

RNA95599|RNS_681_137

TC06000515.hg

g11345453_3p_at

Participates

as a component of

as an input of

FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)

Other forms of this molecule

FANCE [cytosol]

Inferred To

FANCE [nucleoplasm] (Bos taurus)

FANCE [nucleoplasm] (Canis familiaris)

FANCE [nucleoplasm] (Sus scrofa)

Fance [nucleoplasm] (Mus musculus)

Fance [nucleoplasm] (Rattus norvegicus)

Ghost homologue of FANCE [nucleoplasm] (Gallus gallus)

fance [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_068741.1

ENSEMBL

ENSP00000229769, ENST00000229769

OpenTargets

ENSG00000112039

HPA

ENSG00000112039-FANCE

PRO

Q9HB96

Pharos - Targets

Q9HB96

Orphanet

FANCE

PDB

7KZQ, 7KZR, 7KZP, 2ILR, 7KZV, 7KZT, 7KZS

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00597 FANCC	2	FANCC [cytosol] (R-HSA-420801) FANCC [nucleoplasm] (R-HSA-419530)	0.783	6
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.616	4
UniProt:P22413 ENPP1	1	ENPP1 [plasma membrane] (R-HSA-196973)	0.527	2
UniProt:P35052 GPC1	20	HS(4)-GPC1 [plasma membrane] (R-HSA-2076668) HS(6)-GPC1 [plasma membrane] (R-HSA-2076629) HS(2)-GPC1 [plasma membrane] (R-HSA-2076632) HS(1)-GPC1 [plasma membrane] (R-HSA-2076645) HS(3)-GPC1 [plasma membrane] (R-HSA-2076636) HS(5)-GPC1 [plasma membrane] (R-HSA-2076648) GPC1 [plasma membrane] (R-HSA-425952) XylS-GPC1 [Golgi lumen] (R-HSA-2064041) Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064076) GPC1 [Golgi lumen] (R-HSA-2054106) Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064144) GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064189) HS(3)-GPC1 [Golgi lumen] (R-HSA-2076340) HS(4)-GPC1 [Golgi lumen] (R-HSA-2076502) HS(2)-GPC1 [Golgi lumen] (R-HSA-2076296) HS(1)-GPC1 [Golgi lumen] (R-HSA-2076424) Heparan(4)-GPC1 [Golgi lumen] (R-HSA-2076605) Heparan(3)-GPC1 [Golgi lumen] (R-HSA-2076503) Heparan(2)-GPC1 [Golgi lumen] (R-HSA-2076501) Heparan(1)-GPC1 [Golgi lumen] (R-HSA-2076476)	0.527	2
UniProt:Q9UL25 RAB21	3	GGC-RAB21 [early endosome membrane] (R-HSA-8876830) GGC-RAB21 [cytosol] (R-HSA-8873769) RAB21 [cytosol] (R-HSA-8873687)	0.527	2

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