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USP1 [nucleoplasm]
Stable Identifier
R-HSA-419546
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin carboxyl-terminal hydrolase 1, UBP1_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
USP1 autocleavage (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)
MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template [nucleoplasm] (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
USP1:WDR48 [nucleoplasm] (Homo sapiens)
USP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94782 USP1
Gene Names
USP1
Chain
chain:1-785, chain:1-671
Reference Genes
BioGPS Gene:7398 USP1
COSMIC (genes):USP1 USP1
CTD Gene:7398 USP1
dbSNP Gene:7398 USP1
ENSEMBL:ENSG00000162607 USP1
HGNC:12607 USP1
KEGG:hsa:7398 USP1
Monarch:7398 USP1
NCBI Gene:7398 USP1
OMIM:603478 USP1
UCSC:O94782 USP1
Reference Transcript
RefSeq:NM_001017416.1 USP1
RefSeq:NM_001017415.1 USP1
RefSeq:NM_003368.4 USP1
Other Identifiers
11727789_a_at
11739895_a_at
11758989_a_at
16665447
202412_PM_s_at
202412_s_at
202413_PM_s_at
202413_s_at
2339419
2339420
2339421
2339422
2339423
2339424
2339425
2339427
2339428
2339429
2339430
2339431
2339432
2339434
2339435
2339436
2339437
2339439
2339440
2339441
2339442
2339443
2339445
34383_at
7398
74208_s_at
7901867
A_14_P127729
A_14_P201788
A_23_P11652
GE54825
GO:0001501
GO:0003824
GO:0004197
GO:0004843
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006281
GO:0006282
GO:0006508
GO:0008233
GO:0008234
GO:0009411
GO:0016579
GO:0016787
GO:0035520
GO:0043226
GO:0046427
GO:0048856
GO:0140096
GO:1904333
HMNXSV003047640
Hs.35086.0.S1_3p_a_at
ILMN_1678684
ILMN_1696975
ILMN_1737254
PH_hs_0002857
TC01000707.hg
g4507850_3p_a_at
Participates
as a component of
USP1:WDR48 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
USP1(672-785) [nucleoplasm]
USP1(1-671) [nucleoplasm]
Inferred To
usp1 [nucleoplasm]
(Danio rerio)
usp1 [nucleoplasm]
(Xenopus tropicalis)
Homologues of USP1 [nucleoplasm]
(Schizosaccharomyces pombe)
Usp1 [nucleoplasm]
(Mus musculus)
Usp1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of USP1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of USP1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of USP1 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of USP1 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of USP1 [nucleoplasm]
(Saccharomyces cerevisiae)
USP1 [nucleoplasm]
(Bos taurus)
USP1 [nucleoplasm]
(Canis familiaris)
USP1 [nucleoplasm]
(Gallus gallus)
USP1 [nucleoplasm]
(Schizosaccharomyces pombe)
USP1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001017416.1
,
NP_003359.3
,
NP_001017415.1
ZINC - World Drugs
UBP1_HUMAN
Guide to Pharmacology - Targets
2428
OpenTargets
ENSG00000162607
ENSEMBL
ENST00000339950
,
ENSP00000343526
,
ENST00000371146
,
ENSP00000360188
ZINC - FDA approved
UBP1_HUMAN
ZINC - Substances
UBP1_HUMAN
ZINC target
O94782
PRO
O94782
PDB
7AY2
,
7AY1
,
8A9J
,
7AY0
,
7ZH3
,
7ZH4
,
6DO5
,
8A9K
IntEnz
3.4.19.12
HPA
ENSG00000162607-USP1
Pharos - Targets
O94782
ZINC - Predictions - Purchasable
UBP1_HUMAN
HMDB Protein
HMDBP10123
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TAF3 WDR48
3
WDR48 [nucleoplasm]
(R-HSA-419549)
WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol]
(R-HSA-9673617)
p-12Y-WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol]
(R-HSA-9673645)
0.823
8
UniProt:O60346 PHLPP1
1
PHLPP1 [cytosol]
(R-HSA-199421)
0.745
7
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.725
4
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.527
2
UniProt:Q6ZVD8 PHLPP2
1
PHLPP2 [cytosol]
(R-HSA-2327837)
0.527
2
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