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PALB2 [nucleoplasm]
Stable Identifier
R-HSA-419548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Partner and localizer of BRCA2, PALB2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
D-loop extension by DNA polymerases (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
CX3 complex binds D-loop structures (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
BLM mediates dissolution of double Holliday junction (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
FIGNL1 binds RAD51 (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
Impaired BRCA2 binding to PALB2 (Homo sapiens)
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
PALB2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86YC2 PALB2
Gene Names
PALB2, FANCN
Chain
chain:1-1186
Reference Genes
BioGPS Gene:79728 PALB2
COSMIC (genes):PALB2 PALB2
CTD Gene:79728 PALB2
dbSNP Gene:79728 PALB2
ENSEMBL:ENSG00000083093 PALB2
ENSEMBL_homo_sapiens_GENE:ENSG00000083093.11 PALB2
HGNC:26144 PALB2
KEGG Gene (Homo sapiens):79728 PALB2
Monarch:79728 PALB2
NCBI Gene:79728 PALB2
OMIM:610355 PALB2
UCSC:Q86YC2 PALB2
Reference Transcript
RefSeq:NM_024675.3 PALB2
Other Identifiers
11722944_at
16825104
219530_PM_at
219530_at
3685330
3685331
3685332
3685333
3685335
3685337
3685338
3685339
3685341
3685344
3685345
3685346
3685347
3685348
3685349
3685350
3685351
3685352
3685354
3685355
3685358
3685359
47111_at
79728
8000329
A_23_P129569
GE87453
GO:0000724
GO:0001701
GO:0001756
GO:0001833
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0006281
GO:0006310
GO:0006915
GO:0006974
GO:0007498
GO:0009887
GO:0012501
GO:0016607
GO:0032991
GO:0035264
GO:0036342
GO:0043066
GO:0043226
GO:0048568
GO:0048856
GO:1990391
HMNXSV003032667
ILMN_1723793
PH_hs_0025983
TC16000967.hg
g13375939_3p_at
Participates
as an input of
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
as an output of
BLM mediates dissolution of double Holliday junction (Homo sapiens)
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
D-loop dissociation and strand annealing (Homo sapiens)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
as a component of
BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PALB2 Y28C [nucleoplasm]
PALB2 L35P [nucleoplasm]
PALB2 L24S [nucleoplasm]
PALB2 L21A [nucleoplasm]
PALB2 R37H [nucleoplasm]
PALB2 L21F [nucleoplasm]
PALB2 E12* [nucleoplasm]
PALB2 R37C [nucleoplasm]
PALB2 L35F [nucleoplasm]
PALB2 L947F [nucleoplasm]
PALB2 G1043D [nucleoplasm]
PALB2 T1030I [nucleoplasm]
PALB2 T841Qfs*10 [nucleoplasm]
PALB2 L1119P [nucleoplasm]
PALB2 L947S [nucleoplasm]
PALB2 L1143P [nucleoplasm]
PALB2 L1070P [nucleoplasm]
PALB2 C77Vfs*100 [nucleoplasm]
PALB2 L939W [nucleoplasm]
PALB2 L961P [nucleoplasm]
PALB2 W912G [nucleoplasm]
PALB2 L531Cfs*30 [nucleoplasm]
PALB2 G1043A [nucleoplasm]
PALB2 W1140G [nucleoplasm]
PALB2 G937R [nucleoplasm]
PALB2 I944N [nucleoplasm]
PALB2 Y551* [nucleoplasm]
PALB2 G1121Vfs*3 [nucleoplasm]
PALB2 L1006Ffs*5 [nucleoplasm]
PALB2 L253Yfs*26 [nucleoplasm]
PALB2 G1166Vfs*25 [nucleoplasm]
PALB2 M723Vfs*21 [nucleoplasm]
PALB2 I76Yfs*101 [nucleoplasm]
PALB2 V132Afs*45 [nucleoplasm]
PALB2 F440Lfs*12 [nucleoplasm]
PALB2 Q988* [nucleoplasm]
PALB2 R794Sfs*57 [nucleoplasm]
PALB2 T799Lfs*53 [nucleoplasm]
PALB2 E956Kfs*6 [nucleoplasm]
PALB2 P522Qfs*39 [nucleoplasm]
PALB2 Y1108Sfs*16 [nucleoplasm]
PALB2 E1010* [nucleoplasm]
PALB2 W898Efs*29 [nucleoplasm]
PALB2 F816Sfs*35 [nucleoplasm]
PALB2 P1009Lfs*6 [nucleoplasm]
PALB2 F404Sfs*7 [nucleoplasm]
PALB2 H130Tfs*47 [nucleoplasm]
PALB2 I265Tfs*5 [nucleoplasm]
PALB2 K1098Nfs*23 [nucleoplasm]
PALB2 A935* [nucleoplasm]
PALB2 M296* [nucleoplasm]
PALB2 N1039Ifs*2 [nucleoplasm]
PALB2 A995Cfs*16 [nucleoplasm]
PALB2 E230* [nucleoplasm]
PALB2 S172Gfs*4 [nucleoplasm]
PALB2 Q251* [nucleoplasm]
PALB2 E669Gfs*3 [nucleoplasm]
PALB2 D715Efs*2 [nucleoplasm]
PALB2 C882Wfs*3 [nucleoplasm]
PALB2 R37Cfs*5 [nucleoplasm]
PALB2 Y1183* [nucleoplasm]
PALB2 I1037T [nucleoplasm]
PALB2 W575* [nucleoplasm]
PALB2 S518* [nucleoplasm]
PALB2 Q370* [nucleoplasm]
PALB2 L451* [nucleoplasm]
PALB2 E658* [nucleoplasm]
PALB2 K346* [nucleoplasm]
PALB2 E263* [nucleoplasm]
PALB2 Y409* [nucleoplasm]
PALB2 R753* [nucleoplasm]
PALB2 K43Rfs*10 [nucleoplasm]
PALB2 E545* [nucleoplasm]
PALB2 H432Ffs*9 [nucleoplasm]
PALB2 E956* [nucleoplasm]
PALB2 Q613* [nucleoplasm]
PALB2 Q1056* [nucleoplasm]
PALB2 G796* [nucleoplasm]
PALB2 E667* [nucleoplasm]
PALB2 Q1091* [nucleoplasm]
PALB2 E384* [nucleoplasm]
PALB2 W1038* [nucleoplasm]
PALB2 E1002* [nucleoplasm]
PALB2 Q822* [nucleoplasm]
PALB2 S254* [nucleoplasm]
PALB2 E860* [nucleoplasm]
PALB2 Q66* [nucleoplasm]
PALB2 L1172P [nucleoplasm]
PALB2 L857* [nucleoplasm]
PALB2 E943* [nucleoplasm]
PALB2 Q559* [nucleoplasm]
PALB2 R414* [nucleoplasm]
PALB2 G808* [nucleoplasm]
PALB2 Q228* [nucleoplasm]
PALB2 E884* [nucleoplasm]
PALB2 L176Nfs*3 [nucleoplasm]
PALB2 Q60Rfs*7 [nucleoplasm]
PALB2 L972Q [nucleoplasm]
PALB2 I76Mfs*4 [nucleoplasm]
PALB2 N450Ifs*2 [nucleoplasm]
PALB2 I429Rfs*22 [nucleoplasm]
PALB2 I1035Mfs*6 [nucleoplasm]
PALB2 [cytosol]
PALB2 N280Tfs*8 [nucleoplasm]
PALB2 M296Nfs*7 [nucleoplasm]
PALB2 G1043C [nucleoplasm]
PALB2 L304* [nucleoplasm]
PALB2 P656Qfs*4 [nucleoplasm]
PALB2 F606Sfs*10 [nucleoplasm]
PALB2 W877Gfs*12 [nucleoplasm]
PALB2 I281Nfs*2 [nucleoplasm]
PALB2 S299Yfs*3 [nucleoplasm]
Inferred To
Palb2 [nucleoplasm]
(Mus musculus)
Palb2 [nucleoplasm]
(Rattus norvegicus)
PALB2 [nucleoplasm]
(Bos taurus)
PALB2 [nucleoplasm]
(Canis familiaris)
PALB2 [nucleoplasm]
(Gallus gallus)
PALB2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_078951.2
OpenTargets
ENSG00000083093
HPA
ENSG00000083093-PALB2
GeneCards
Q86YC2
Ensembl
ENST00000261584
,
ENSG00000083093
,
ENSP00000261584
PRO
Q86YC2
Pharos - Targets
Q86YC2
Orphanet
16873
PDB
2W18
,
3EU7
,
7S4A
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51587 BRCA2
20
BRCA2 D2983Ffs*34 [cytosol]
(R-HSA-9709538)
BRCA2 K2555* [cytosol]
(R-HSA-9711337)
BRCA2 N2553Tfs*95 [cytosol]
(R-HSA-9712872)
BRCA2 T2685Hfs*9 [cytosol]
(R-HSA-9712879)
BRCA2 K2674Rfs*2 [cytosol]
(R-HSA-9712610)
BRCA2 S3231* [cytosol]
(R-HSA-9711458)
BRCA2 I2675Dfs*6 [cytosol]
(R-HSA-9712869)
BRCA2 R2625* [cytosol]
(R-HSA-9711482)
BRCA2 E3071* [cytosol]
(R-HSA-9711354)
BRCA2 V2716Wfs*17 [cytosol]
(R-HSA-9712761)
BRCA2 W2586* [cytosol]
(R-HSA-9711487)
BRCA2 P2767Lfs*10 [cytosol]
(R-HSA-9712509)
BRCA2 K3032* [cytosol]
(R-HSA-9711485)
BRCA2 S2835* [cytosol]
(R-HSA-9711345)
BRCA2 Y3006* [cytosol]
(R-HSA-9711222)
BRCA2 L2926* [cytosol]
(R-HSA-9711348)
BRCA2 R3128* [cytosol]
(R-HSA-9711177)
BRCA2 E2599* [cytosol]
(R-HSA-9711304)
BRCA2 E2571* [cytosol]
(R-HSA-9711560)
BRCA2 Y2977* [cytosol]
(R-HSA-9711182)
0.972
30
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.909
27
UniProt:Q06609 RAD51
2
RAD51 [nucleoplasm]
(R-HSA-62637)
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
0.845
9
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.8
6
UniProt:Q9UBU8 MORF4L1
1
MORF4L1 [nucleoplasm]
(R-HSA-3321982)
0.725
6
UniProt:Q9UBU8-2 MORF4L1
0.713
3
UniProt:Q9Y253 POLH
2
MonoUb-K682,K686,K694,K709-POLH [nucleoplasm]
(R-HSA-5655163)
POLH [nucleoplasm]
(R-HSA-110287)
0.672
7
UniProt:O43502 RAD51C
1
RAD51C [nucleoplasm]
(R-HSA-217039)
0.612
10
UniProt:O43542 XRCC3
1
XRCC3 [nucleoplasm]
(R-HSA-5685303)
0.577
3
IntAct:EBI-4399559 UBIQ
0.544
2
UniProt:Q15014 MORF4L2
1
MORF4L2 [nucleoplasm]
(R-HSA-3322945)
0.527
3
UniProt:P51784 USP11
1
USP11 [cytosol]
(R-HSA-391303)
0.499
2
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