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GRIN2B [plasma membrane]
Stable Identifier
R-HSA-419558
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glutamate (NMDA) receptor subunit epsilon-2, NR2B
Locations in the PathwayBrowser for interactor UniProt:Q5TCQ9
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates neuronal receptors and channels (Homo sapiens)
GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)
GRIN2B [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FYN (Homo sapiens)
Activated FYN binds GRIN2B (Homo sapiens)
GRIN2B [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13224 GRIN2B
Gene Names
GRIN2B, NMDAR2B
Chain
signal peptide:1-26, chain:27-1484
Reference Genes
BioGPS Gene:2904 GRIN2B
COSMIC (genes):GRIN2B GRIN2B
CTD Gene:2904 GRIN2B
dbSNP Gene:2904 GRIN2B
ENSEMBL:ENSG00000273079 GRIN2B
ENSEMBL_homo_sapiens_GENE:ENSG00000273079.7 GRIN2B
HGNC:4586 GRIN2B
KEGG Gene (Homo sapiens):2904 GRIN2B
Monarch:2904 GRIN2B
NCBI Gene:2904 GRIN2B
OMIM:138252 GRIN2B
UCSC:Q13224 GRIN2B
Reference Transcript
RefSeq:XM_011520628.2 GRIN2B
RefSeq:NM_000834.3 GRIN2B
RefSeq:XM_017019219.1 GRIN2B
RefSeq:XM_011520629.2 GRIN2B
Other Identifiers
11737021_at
11737022_at
16761707
210411_PM_s_at
210411_s_at
210412_PM_at
210412_at
239095_PM_at
239095_at
2904
32489_at
3445310
3445312
3445314
3445316
3445318
3445319
3445321
3445323
3445325
3445327
3445328
3445329
3445330
3445335
3445336
3445349
3445350
3445351
3445352
3445354
3445363
3445390
3445433
3445458
3445459
3445460
3445464
3445465
3445466
51319_at
7961422
A_19_P00809362
A_23_P151264
A_32_P144072
GE58237
GE756458
GO:0001540
GO:0004970
GO:0004972
GO:0005215
GO:0005216
GO:0005515
GO:0005737
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005783
GO:0005789
GO:0005856
GO:0005886
GO:0006811
GO:0007215
GO:0007268
GO:0007420
GO:0007611
GO:0008270
GO:0009986
GO:0014069
GO:0015276
GO:0016020
GO:0016594
GO:0016595
GO:0017146
GO:0019722
GO:0022849
GO:0022890
GO:0023052
GO:0031410
GO:0034220
GO:0034330
GO:0035235
GO:0035249
GO:0038023
GO:0043005
GO:0043226
GO:0045202
GO:0045211
GO:0045471
GO:0046872
GO:0048167
GO:0048168
GO:0048856
GO:0050877
GO:0051290
GO:0051968
GO:0055085
GO:0060079
GO:0060089
GO:0060291
GO:0065003
GO:0097060
GO:0097553
GO:0098655
GO:0098839
GO:0098976
GO:0099505
GO:0099507
GO:1902951
GO:1904062
GO:1904315
GO:2000463
GO:2001056
HMNXSV003034735
HMNXSV003043145
Hs.292597.0.A1_3p_at
ILMN_1884244
ILMN_1908923
PH_hs_0000159
TC12001265.hg
U11287_at
U28758_s_at
g1899201_3p_a_at
g560546_3p_at
Participates
as an input of
Activated FYN binds GRIN2B (Homo sapiens)
as a component of
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:GRIN2B [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B:GRIN3A tri-heterotetramer [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B:GRIN3B tri-heterotetramer [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer [plasma membrane] (Homo sapiens)
GRIN1:GRIN2B:GRIN2D tri-heterotetramer [plasma membrane] (Homo sapiens)
as a member of
NR2 subunits [plasma membrane] (Homo sapiens)
as an output of
GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)
Other forms of this molecule
p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]
p-Y1474-GRIN2B [plasma membrane]
GRIN2B [transport vesicle membrane]
GRIN2B [endoplasmic reticulum membrane]
p-Y-GRIN2B [plasma membrane]
Inferred To
GRIN2B [plasma membrane]
(Canis familiaris)
GRIN2B [plasma membrane]
(Gallus gallus)
GRIN2B [plasma membrane]
(Mus musculus)
GRIN2B [plasma membrane]
(Rattus norvegicus)
GRIN2B [plasma membrane]
(Sus scrofa)
Nmdar2 [plasma membrane]
(Drosophila melanogaster)
grin2b [plasma membrane]
(Xenopus tropicalis)
nmr-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011518931.1
,
XP_011518930.1
,
XP_016874708.1
,
NP_000825.2
ZINC - World Drugs
NMDE2_HUMAN
Guide to Pharmacology - Targets
457
OpenTargets
ENSG00000273079
ZINC - Substances
NMDE2_HUMAN
ZINC target
Q13224
ZINC - Biogenic
NMDE2_HUMAN
PRO
Q13224
PDB
7UJR
,
7KL2
,
7UJQ
,
7UJS
,
7EU8
,
7UJT
,
5EWJ
,
5EWM
,
7KL1
,
7UIS
,
7UJP
,
5EWL
,
7KL0
ZINC - Investigational
NMDE2_HUMAN
ZINC - Metabolites
NMDE2_HUMAN
GeneCards
Q13224
HPA
ENSG00000273079-GRIN2B
Ensembl
ENSP00000477455
,
ENST00000609686
,
ENSG00000273079
Pharos - Targets
Q13224
Orphanet
20146
ZINC - Predictions - Purchasable
NMDE2_HUMAN
HMDB Protein
HMDBP01644
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78352 DLG4
3
DLG4 [cytosol]
(R-HSA-6794267)
DLG4 [endocytic vesicle membrane]
(R-HSA-416847)
DLG4 [plasma membrane]
(R-HSA-202135)
0.755
4
UniProt:Q12959 DLG1
4
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [plasma membrane]
(R-HSA-375977)
0.704
4
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.602
3
UniProt:Q62936
2
Dlg3 [cytosol]
(R-RNO-6794232)
Dlg3 [plasma membrane]
(R-RNO-443609)
0.558
4
UniProt:P31016 Dlg4
3
Dlg4 [cytosol]
(R-RNO-6794248)
Dlg4 [endocytic vesicle membrane]
(R-RNO-416847)
Dlg4 [plasma membrane]
(R-RNO-9612601)
0.558
2
UniProt:Q05586-1 GRIN1
0.522
2
UniProt:P62139 PP1A
0.502
2
UniProt:Q5TCQ9 MAGI3
0.488
2
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