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MET [plasma membrane]
Stable Identifier
R-HSA-419603
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hepatocyte growth factor receptor, MET_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q00944
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
InlB binds MET (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates neuronal receptors and channels (Homo sapiens)
MET gene transcription is stimulated by MECP2 (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HGF dimer binds MET (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
MET binds LRIG1 (Homo sapiens)
MET [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08581 MET
Gene Names
MET
Chain
signal peptide:1-24, chain:25-1390
Reference Genes
BioGPS Gene:4233 MET
COSMIC (genes):MET MET
CTD Gene:4233 MET
dbSNP Gene:4233 MET
ENSEMBL:ENSG00000105976 MET
HGNC:7029 MET
KEGG Gene (Homo sapiens):4233 MET
Monarch:4233 MET
NCBI Gene:4233 MET
OMIM:164860 MET
UCSC:P08581 MET
Reference Transcript
RefSeq:NM_000245.3 MET
RefSeq:NM_001127500.2 MET
Other Identifiers
0000380164
11716407_a_at
11716408_a_at
11735116_a_at
11751246_a_at
11752248_a_at
11754144_a_at
1609_g_at
17050591
1812_s_at
203510_at
211599_x_at
213807_x_at
213816_s_at
3020342
3020344
3020348
3020349
3020350
3020363
3020365
3020366
3020367
3020374
3020377
3020378
3020379
3020380
3020381
3020382
3020384
3020385
3020387
3020390
3020391
3020392
3020393
3020395
3020396
3020397
3020399
3020401
3020402
3020403
3020404
3020405
3020406
3020407
3020408
3020409
3020410
3020411
3020412
35684_at
4233
46302_at
8135601
A_14_P102324
A_14_P113351
A_14_P119122
A_14_P137799
A_23_P145844
A_23_P145846
A_23_P359245
GE57468
GO:0000165
GO:0000166
GO:0000902
GO:0001886
GO:0001889
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005008
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006810
GO:0006909
GO:0006914
GO:0006950
GO:0007010
GO:0007165
GO:0007166
GO:0007169
GO:0007275
GO:0007399
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0009925
GO:0009986
GO:0010507
GO:0016020
GO:0016021
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017154
GO:0018108
GO:0019899
GO:0019903
GO:0022607
GO:0030154
GO:0030182
GO:0031016
GO:0031116
GO:0032991
GO:0033674
GO:0034641
GO:0035024
GO:0035635
GO:0040011
GO:0042592
GO:0042802
GO:0043167
GO:0043235
GO:0044403
GO:0045944
GO:0048012
GO:0048754
GO:0048856
GO:0048870
GO:0050918
GO:0051497
GO:0051897
GO:0061436
GO:0065003
GO:0070495
GO:0071526
GO:1901299
GO:1905098
GO:2001028
Hs.285754.0.S2_3p_at
Hs.285754.1.S1_3p_a_at
ILMN_1715175
PH_hs_0025104
TC07000722.hg
g625085_3p_s_at
Participant Of
output
MET gene transcription is stimulated by MECP2
input
HGF dimer binds MET
InlB binds MET
MET binds LRIG1
hasComponent
HGF dimer:MET [plasma membrane]
InlB:MET [plasma membrane]
MET:LRIG1 [plasma membrane]
MET:p-Y-PLXNB1 [plasma membrane]
MET:Ub-LRIG1 [plasma membrane]
Plexin-B1:Met [plasma membrane]
Other forms of this molecule
p-Y1349,Y1356-MET [plasma membrane]
p-Y1234,Y1235,Y1356-MET [plasma membrane]
p-Y1003,4Y-MET [plasma membrane]
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
Inferred To
MET [plasma membrane] (Caenorhabditis elegans)
MET [plasma membrane] (Gallus gallus)
Ghost homologue of MET [plasma membrane] (Canis familiaris)
Ghost homologue of MET [plasma membrane] (Sus scrofa)
Met [plasma membrane] (Mus musculus)
Met [plasma membrane] (Rattus norvegicus)
met [plasma membrane] (Danio rerio)
met [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_000236.2
,
NP_001120972.1
ZINC - World Drugs
MET_HUMAN
OpenTargets
ENSG00000105976
ZINC - FDA approved
MET_HUMAN
ZINC - Substances
MET_HUMAN
ZINC target
P08581
ZINC - Biogenic
MET_HUMAN
PRO
P08581
PDB
3RHK
,
5YA5
,
5UAB
,
2UZY
,
3VW8
,
2WD1
,
5HOR
,
4R1V
,
5LSP
,
4DEH
,
1R0P
,
6SD9
,
3DKF
,
1UX3
,
4AP7
,
4GG7
,
4O3T
,
3ZCL
,
3F66
,
3CE3
,
3EFK
,
2WKM
,
6GCU
,
5HOA
,
3I5N
,
3Q6U
,
5EYD
,
3ZC5
,
4K3J
,
5HLW
,
4KNB
,
3CD8
,
3L8V
,
3CTH
,
4MXC
,
3U6I
,
4XYF
,
6SDD
,
2RFN
,
5HNI
,
3DKG
,
4DEI
,
6I04
,
2UZX
,
3CCN
,
3ZZE
,
1SSL
,
3DKC
,
3LQ8
,
3BUX
,
4DEG
,
4R1Y
,
4IWD
,
4O3U
,
1SHY
,
3QTI
,
3A4P
,
3R7O
,
1FYR
,
3EFJ
,
4AOI
,
4GG5
,
2WGJ
,
6UBW
,
3ZBX
,
5T3Q
,
3C1X
,
1R1W
,
3F82
,
5HO6
,
2G15
,
3Q6W
,
5EOB
,
4XMO
,
2RFS
,
5EYC
,
3U6H
,
5DG5
,
3CTJ
,
5HTI
,
5UAD
,
6SDC
,
4EEV
,
3ZXZ
,
6SDE
ZINC - Investigational
MET_HUMAN
ZINC - Metabolites
MET_HUMAN
HPA
ENSG00000105976-MET
GeneCards
P08581
Ensembl
ENSP00000410980
,
ENST00000397752
,
ENST00000318493
,
ENSP00000380860
,
ENST00000436117
,
ENSP00000317272
,
ENSG00000105976
Orphanet
16392
ZINC - Predictions - Purchasable
MET_HUMAN
HMDB Protein
HMDBP09447
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
39
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
CBL R420* [cytosol]
(R-HSA-9706208)
CBL H398D [cytosol]
(R-HSA-9706631)
CBL Y371C [cytosol]
(R-HSA-9706694)
CBL G375S [cytosol]
(R-HSA-9706214)
CBL Y371D [cytosol]
(R-HSA-9706687)
CBL Y371S [cytosol]
(R-HSA-9706674)
CBL P417S [cytosol]
(R-HSA-9706642)
CBL H398N [cytosol]
(R-HSA-9706641)
CBL R420P [cytosol]
(R-HSA-9706193)
CBL Y371N [cytosol]
(R-HSA-9706679)
CBL R499Q [cytosol]
(R-HSA-9706677)
CBL R420L [cytosol]
(R-HSA-9706197)
CBL P417H [cytosol]
(R-HSA-9706644)
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
0.864
17
UniProt:P14210 HGF
5
HGF(495-728) [platelet alpha granule lumen]
(R-HSA-141764)
HGF(32-494) [platelet alpha granule lumen]
(R-HSA-139866)
pro-HGF [extracellular region]
(R-HSA-6800218)
HGF(495-728) [extracellular region]
(R-HSA-141767)
HGF(32-494) [extracellular region]
(R-HSA-56497)
0.851
7
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.8
8
UniProt:O43157 PLXNB1
2
PLXNB1 [plasma membrane]
(R-HSA-3008951)
p-Y-PLXNB1 [plasma membrane]
(R-HSA-419609)
0.775
9
UniProt:Q12913 PTPRJ
2
PTPRJ [plasma membrane]
(R-HSA-6785269)
PTPRJ [specific granule membrane]
(R-HSA-6799570)
0.733
5
UniProt:P18031 PTPN1
1
PTPN1 [cytosol]
(R-HSA-210625)
0.713
3
UniProt:P12931 SRC
6
p-Y416-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.702
4
UniProt:P14210-6 HGF
0.676
3
UniProt:P0DQD2 inlB
1
InlB [cell wall]
(R-LMO-9637760)
0.618
4
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.609
2
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
0.609
13
UniProt:Q00944
11
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
PTK2(1-772) [cytosol]
(R-GGA-202827)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
PTK2 [cytosol]
(R-GGA-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
0.602
5
UniProt:Q96S59 RANBP9
1
RANBP9 [cytosol]
(R-HSA-374586)
0.593
3
UniProt:P35918 Kdr
3
Kdr [plasma membrane]
(R-MMU-195382)
Mouse Vegfr2-Human CSF1R fusion protein [plasma membrane]
(R-MMU-5218738)
phospho-Kdr [plasma membrane]
(R-MMU-4420103)
0.591
3
UniProt:Q16827 PTPRO
1
PTPRO [plasma membrane]
(R-HSA-9603761)
0.59
2
UniProt:Q08048 Hgf
6
Hgf [platelet alpha granule lumen]
(R-MMU-139866)
Hgf beta [extracellular region]
(R-MMU-1264804)
Hgf [platelet alpha granule lumen]
(R-MMU-141764)
Hgf [extracellular region]
(R-MMU-6800218)
Hgf [extracellular region]
(R-MMU-141767)
Hgf [extracellular region]
(R-MMU-56497)
0.558
3
UniProt:P41218 MNDA
3
MNDA [extracellular region]
(R-HSA-6806244)
MNDA [azurophil granule lumen]
(R-HSA-6799237)
MNDA [ficolin-1-rich granule lumen]
(R-HSA-6800897)
0.556
3
UniProt:O15031 PLXB2
0.524
2
UniProt:Q96EY1-2 DNAJA3
0.524
2
UniProt:Q9ULL4 PLXNB3
1
PLXNB3 [plasma membrane]
(R-HSA-416675)
0.524
2
UniProt:Q86VI4 LAP4B
0.463
3
UniProt:Q96EY1 DNJA3
0.463
2
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